Academic Journal
Clinical parameters of ovarian hyperstimulation syndrome following different hormonal triggers of oocyte maturation in IVF treatment
| العنوان: | Clinical parameters of ovarian hyperstimulation syndrome following different hormonal triggers of oocyte maturation in IVF treatment |
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| المؤلفون: | Abbara, A., Islam, R., Clarke, S.A., Jeffers, L., Christopoulos, G., Comninos, A.N., Salim, R., Lavery, S.A., Vuong, T.N.L., Humaidan, P., Kelsey, T.W., Trew, G.H., Dhillo, W.S. |
| المساهمون: | Biotechnology and Biological Sciences Research Council, Medical Research Council, Wellcome Trust, National Institute for Health Research |
| المصدر: | Clinical Endocrinology ; volume 88, issue 6, page 920-927 ; ISSN 0300-0664 1365-2265 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2018 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Summary Objective Ovarian hyperstimulation syndrome ( OHSS ) is a serious iatrogenic condition, predominantly related to the hormone used to induce oocyte maturation during IVF treatment. Kisspeptin is a hypothalamic neuropeptide that has recently been demonstrated to safely trigger final oocyte maturation during IVF treatment even in women at high risk of OHSS . However, to date, the safety of kisspeptin has not been compared to current hormonal triggers of oocyte maturation. Design We conducted a retrospective single‐centre cohort study investigating symptoms and clinical parameters of early OHSS in women at high risk of OHSS (antral follicle count or total number of follicles on day of trigger ≥23) triggered with human chorionic gonadotrophin ( hCG ) (n = 40), Gn RH agonist (Gn RH a; n = 99) or kisspeptin (n = 122) at Hammersmith Hospital IVF unit, London, UK (2013‐2016). Results Clinical Parameters of OHSS : Median ovarian volume was larger following hCG (138 ml) than Gn RH a (73 ml; P < .0001), and in turn kisspeptin (44 ml; P < .0001). Median ovarian volume remained enlarged 20‐fold following hCG , 8‐fold following Gn RH a and 5‐fold following kisspeptin compared to prestimulation ovarian volumes. Mean (± SD ) ascitic volumes were lesser following Gn RH a (9 ± 44 ml) and kisspeptin (5 ± 8 ml) than hCG (62 ± 84 ml; P < .0001). Symptoms of OHSS were most frequent following hCG and least frequent following kisspeptin. Diagnosis of OHSS : The odds ratio for OHSS diagnosis was 33.6 ( CI 12.6‐89.5) following hCG and 3.6 ( CI 1.8‐7.1) following Gn RH a, when compared to kisspeptin. Conclusion Triggering oocyte maturation by inducing endogenous gonadotrophin release is preferable to the use of exogenous hCG in women at high risk of OHSS . |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/cen.13569 |
| الاتاحة: | http://dx.doi.org/10.1111/cen.13569 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcen.13569 https://onlinelibrary.wiley.com/doi/pdf/10.1111/cen.13569 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.2D3AE651 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/cen.13569 |
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