Academic Journal

A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy

التفاصيل البيبلوغرافية
العنوان: A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy
المؤلفون: Hajek, Peter, Phillips-Waller, Anna, Przulj, Dunja, Pesola, Francesca, Myers Smith, Katie, Bisal, Natalie, Li, Jinshuo, Parrott, Steve, Sasieni, Peter, Dawkins, Lynne, Ross, Louise, Goniewicz, Maciej, Wu, Qi, McRobbie, Hayden J
سنة النشر: 2019
المجموعة: White Rose Research Online (Universities of Leeds, Sheffield & York)
الوصف: BACKGROUND: E-cigarettes are commonly used in attempts to stop smoking, but evidence is limited regarding their effectiveness as compared with that of nicotine products approved as smoking-cessation treatments. METHODS: We randomly assigned adults attending U.K. National Health Service stop-smoking services to either nicotine-replacement products of their choice, including product combinations, provided for up to 3 months, or an e-cigarette starter pack (a second-generation refillable e-cigarette with one bottle of nicotine e-liquid [18 mg per milliliter]), with a recommendation to purchase further e-liquids of the flavor and strength of their choice. Treatment included weekly behavioral support for at least 4 weeks. The primary outcome was sustained abstinence for 1 year, which was validated biochemically at the final visit. Participants who were lost to follow-up or did not provide biochemical validation were considered to not be abstinent. Secondary outcomes included participant-reported treatment usage and respiratory symptoms. RESULTS: A total of 886 participants underwent randomization. The 1-year abstinence rate was 18.0% in the e-cigarette group, as compared with 9.9% in the nicotine-replacement group (relative risk, 1.83; 95% confidence interval [CI], 1.30 to 2.58; P<0.001). Among participants with 1-year abstinence, those in the e-cigarette group were more likely than those in the nicotine-replacement group to use their assigned product at 52 weeks (80% [63 of 79 participants] vs. 9% [4 of 44 participants]). Overall, throat or mouth irritation was reported more frequently in the e-cigarette group (65.3%, vs. 51.2% in the nicotine-replacement group) and nausea more frequently in the nicotine-replacement group (37.9%, vs. 31.3% in the e-cigarette group). The e-cigarette group reported greater declines in the incidence of cough and phlegm production from baseline to 52 weeks than did the nicotine-replacement group (relative risk for cough, 0.8; 95% CI, 0.6 to 0.9; relative risk for phlegm, 0.7; 95% CI, ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: text
اللغة: English
Relation: https://eprints.whiterose.ac.uk/142483/1/NEJM_TEC_Hajek_et_al_2019.pdf; https://eprints.whiterose.ac.uk/142483/8/Supplementary_files_21_Jan_2019_clean.pdf; Hajek, Peter, Phillips-Waller, Anna, Przulj, Dunja et al. (11 more authors) (2019) A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy. New England Journal of Medicine. pp. 629-637. ISSN 1533-4406
DOI: 10.1056/NEJMoa1808779
الاتاحة: https://eprints.whiterose.ac.uk/142483/
https://eprints.whiterose.ac.uk/142483/1/NEJM_TEC_Hajek_et_al_2019.pdf
https://eprints.whiterose.ac.uk/142483/8/Supplementary_files_21_Jan_2019_clean.pdf
https://doi.org/10.1056/NEJMoa1808779
رقم الانضمام: edsbas.2D328FC9
قاعدة البيانات: BASE