Academic Journal
Change of Fecal Flora and Effectiveness of the Short-term VSL#3 Probiotic Treatment in Patients With Functional Constipation
| العنوان: | Change of Fecal Flora and Effectiveness of the Short-term VSL#3 Probiotic Treatment in Patients With Functional Constipation |
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| المؤلفون: | Seong-Eun Kim, Suck Chei Choi, Kyung Sik Park, Moo In Park, Jeong Eun Shin, Tae Hee Lee, Kee Wook Jung, Hoon Sup Koo, Seung-Jae Myung, Constipation Research group of Korean Society of Neurogastroenterology and Motility |
| المساهمون: | 박경식, Park, Kyung Sik, Dept. of Internal Medicine (내과학) |
| بيانات النشر: | School of Medicine |
| سنة النشر: | 2015 |
| المجموعة: | Keimyung University Medical Library: KUMeL Repository |
| مصطلحات موضوعية: | Constipation, Microbiome, Probiotics |
| الوصف: | Background/Aims: We investigated gut flora characteristics in patients with functional constipation (FC) and influences of short-term treatment with VSL#3 probiotic on flora and symptom improvement. Methods: Thirty patients fulfilling Rome III criteria for FC and 30 controls were enrolled. Fecal samples were obtained before and after VSL#3 intake (one sachet twice daily for 2 weeks) and flora were examined by quantitative real-time polymerase chain reaction (qRT-PCR). Symptom changes were also investigated. Results: The fold differences in Bifidobacterium and Bacteroides species were significantly lower in feces from FC, compared to in controls (P = 0.030 and P = 0.021). After taking VSL#3, the fold differences in Lactobacillus, Bifidobacterium and Bacteroides species increased in controls (P = 0.022, P = 0.018, and P = 0.076), but not in FC. Mean Bristol scores and complete spontaneous bowel movements (CSBMs)/week increased significantly in FC after ingesting VSL#3 (both P < 0.001). Relief of subjective CSBM frequency, stool consistency and abdominal bloating were reported in 70%, 60%, and 47% of patients. After VSL#3 cessation, 44.4% of patients with symptom improvement experienced constipation recurrence mostly within one month. Conclusions: Bifidobacterium and Bacteroides species might be quantitatively altered in FC. A short-term VSL#3 treatment can improve clinical symptoms of FC. Further studies are needed to investigate VSL#3’s additional effects beyond altering gut flora to allevate constipation. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 2093-0879 |
| Relation: | Journal of Neurogastroenterology and Motility, Vol.21(1) : 111-120, 2015; oak-aaa-2495; http://kumel.medlib.dsmc.or.kr/handle/2015.oak/33832 |
| DOI: | 10.5056/jnm14048 |
| الاتاحة: | http://kumel.medlib.dsmc.or.kr/handle/2015.oak/33832 https://doi.org/10.5056/jnm14048 |
| Rights: | BY_NC_ND ; http://creativecommons.org/licenses/by-nc-nd/2.0/kr |
| رقم الانضمام: | edsbas.2D2C2C02 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20930879 |
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| DOI: | 10.5056/jnm14048 |