Academic Journal
AMPK signaling in the nucleus accumbens core mediates cue-induced reinstatement of cocaine seeking
| العنوان: | AMPK signaling in the nucleus accumbens core mediates cue-induced reinstatement of cocaine seeking |
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| المؤلفون: | Gao, Xue-Jiao, Yuan, Kai, Cao, Lu, Yan, Wei, Luo, Yi-Xiao, Jian, Min, Liu, Jian-Feng, Fang, Qin, Wang, Ji-Shi, Han, Ying, Shi, Jie, Lu, Lin |
| المساهمون: | Han, Y, Shi, J, Lu, L (reprint author), Peking Univ, Natl Inst Drug Dependence, Beijing, Peoples R China., Lu, L (reprint author), Peking Univ, Beijing Key Lab Drug Dependence, Beijing, Peoples R China., Han, Y (reprint author), Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Hlth Sci Ctr, Beijing, Peoples R China., Lu, L (reprint author), Peking Univ, Hosp 6, Natl Clin Res Ctr Mental Disorders, Inst Mental Hlth,Key Lab Mental Hlth,Minist Hlth, Beijing, Peoples R China., Lu, L (reprint autho, Peking Univ, Natl Inst Drug Dependence, Beijing, Peoples R China., Peking Univ, Beijing Key Lab Drug Dependence, Beijing, Peoples R China., Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Hlth Sci Ctr, Beijing, Peoples R China., Peking Univ, Hosp 6, Natl Clin Res Ctr Mental Disorders, Inst Mental Hlth,Key Lab Mental Hlth,Minist Hlth, Beijing, Peoples R China., Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China., Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing, Peoples R China., Guizhou Med Univ, Affiliated Hosp, Guiyang, Peoples R China., Guizhou Med Univ, Sch Pharm, Guiyang, Peoples R China., Hunan Normal Univ, Dept Pharm, Coll Med, Changsha, Hunan, Peoples R China., Univ Buffalo State Univ New York, Dept Pharmacol & Toxicol, Buffalo, NY USA., Lu, L (reprint author), Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China., Lu, L (reprint author), Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing, Peoples R China. |
| المصدر: | SCI |
| بيانات النشر: | SCIENTIFIC REPORTS |
| سنة النشر: | 2017 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | ACTIVATED PROTEIN-KINASE, RETRIEVAL-EXTINCTION PROCEDURE, MELANIN-CONCENTRATING HORMONE, SYNAPTIC PLASTICITY, DRUG-SEEKING, FOOD-INTAKE, TRANSLATIONAL CONTROL, BASOLATERAL AMYGDALA, CELL-PROLIFERATION, PREFRONTAL CORTEX |
| الوصف: | Relapse to drug seeking can be caused by exposure to drug-associated cues, provoking drug craving even after prolonged abstinence. Recent studies demonstrated that AMP-activated protein kinase (AMPK) regulates neuronal morphology and membrane excitability in neurons. Here, we investigated the role of AMPK activity in the nucleus accumbens (NAc) in relapse to cocaine seeking. We found that exposure to drug-related cues reinstated cocaine-seeking behavior and increased AMPK and p70s6k phosphorylation in the NAc core but not shell. Augmenting AMPK activity by intra-NAc core infusions of the AMPK activator 5-amino-1-beta-D-ribofuranosyl-imidazole-4-carboxamide (AICAR) or adenovirus expressing constitutively active subunits of AMPK decreased cue-induced reinstatement of cocaine seeking and inhibited the mammalian target of rapamycin complex 1 (mTORC1) and extracellular signal-regulated kinase 1/2 (ERK1/2) pathways. In contrast, inhibition of AMPK activity by intra-NAc core infusions of the AMPK inhibitor compound C or adenovirus expressing dominant-negative subunits of AMPK increased cue-induced reinstatement of cocaine seeking and enhanced mTORC1 and ERK1/2 activity. The regulation of AMPK activity in the NAc shell had no effect on cue-induced cocaine seeking. Altogether, these results indicate that AMPK activity in the NAc core is critical for the cue-induced reinstatement of cocaine seeking, which may be mediated by mTORC1 and ERK1/2 signaling. ; National Basic Research Program of China [2015CB856400, 2015CB553503]; Natural Science Foundation of China [81521063, 31230033, 91432303]; Funds for Excellent PhD Graduates of Peking University Health Science Center [BMU20160569] ; SCI(E) ; ARTICLE ; 7 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | SCIENTIFIC REPORTS.2017,7.; 1908234; http://hdl.handle.net/20.500.11897/473911; WOS:000399972900037 |
| DOI: | 10.1038/s41598-017-01043-5 |
| الاتاحة: | https://hdl.handle.net/20.500.11897/473911 https://doi.org/10.1038/s41598-017-01043-5 |
| رقم الانضمام: | edsbas.2D29094D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-017-01043-5 |