Academic Journal
A study of TB-associated immune reconstitution inflammatory syndrome using the consensus case-definition
| العنوان: | A study of TB-associated immune reconstitution inflammatory syndrome using the consensus case-definition |
|---|---|
| المؤلفون: | Sharma, S. K., Dhooria, S., Barwad, P., Kadhiravan, T., Ranjan, S., Miglani, S., Gupta, D. |
| بيانات النشر: | Indian Council of Medical Research |
| سنة النشر: | 2010 |
| المجموعة: | Indian Academy of Sciences: Publication of Fellows |
| مصطلحات موضوعية: | R Medicine |
| الوصف: | Background & Objectives: A considerable proportion of patients with HIV associated tuberculosis (TB) started on highly active antiretroviral therapy (HAART) develop immune reconstitution inflammatory syndrome (IRIS), which is difficult to diagnose in a resource-limited setting. In view of the recently proposed consensus case-definitions for TB-IRIS for use in resource-limited settings we undertook this study to describe the incidence and risk factors of TB associated IRIS in a tertiary care hospital and research centre in north India. Methods: Retrospective analysis of antiretroviral treatment (ART) naive adults started on highly active ART (HAART) from June 2006 to September 2008 was done. Results: Of the 627 patients studied, 237 (38%) had TB at the initiation of HAART. In total, 18 (7.5%) of 237 patients with TB at baseline had paradoxical TB-associated IRIS, and 12 (3%) of 390 patients without TB at baseline developed ART-associated TB. Most IRIS events occurred during the initial 30 days of HAART. Two patients developed TB-associated IRIS after 90 days of HAART. Using univariate analysis, low CD4+ cell count at baseline [64 (28-89) vs. 95 (52-150); P=0.009] and early initiation of HAART [33 (24-41) vs. 48 (35-61) days; P<0.001] were significantly associated with paradoxical TB-associated IRIS. No identifiable risk factors were associated with the development of ART-associated TB. Interpretation & Conclusion: A considerable proportion of patients on HAART develop TB-associated IRIS. The consensus case-definition is a useful tool in resource-limited settings for the diagnosis of TB- associated IRIS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | Sharma, S. K.; Dhooria, S.; Barwad, P.; Kadhiravan, T.; Ranjan, S.; Miglani, S.; Gupta, D. (2010) A study of TB-associated immune reconstitution inflammatory syndrome using the consensus case-definition Indian Journal of Medical Research, 131 . pp. 804-808. ISSN 0971-5916 |
| الاتاحة: | http://repository.ias.ac.in/69275/ http://icmr.nic.in/ijmr/ijmr.htm |
| رقم الانضمام: | edsbas.2C79C229 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |