Academic Journal
New insights into Human Pegivirus-1 (HPgV-1) genotypes diversity in sub-Saharan Africa
| العنوان: | New insights into Human Pegivirus-1 (HPgV-1) genotypes diversity in sub-Saharan Africa |
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| المؤلفون: | Sauvage, Virginie, Gomez, Johanna, Boizeau, Laure, Vandenbogaert, Mathias, Barbier, Léa, Tagny, Claude Tayou, Rakoto Alson, Aimée Olivat, Bizimana, Pascal, Coulibaly, Sekou Oumar, Boullahi, Mohamed Abdallahi, Soumana, Hadiza, Mbensa, Guy, Caro, Valérie, Laperche, Syria |
| المساهمون: | Institut National de la Transfusion Sanguine Paris (INTS), Environnement et Risques infectieux - Environment and Infectious Risks (ERI), Institut Pasteur Paris (IP)-Université Paris Cité (UPCité), Université de Yaoundé I (UY1), National Blood Center Antananarivo, Madagascar (NBC), National Blood Center Bujumbura, Burundi (NBC), National Blood Center Bamako, Mali (NBC), National Blood Center Nouakchott, Mauritania (NBC), National Blood Center Niamey, Niger (NBC), National Blood Center Kinshasa, Democratic Republic of the Congo (NBC), This research was supported by grant number 39-2015 from the “Agence Nationale de Sécurité du Medicament et des Produits de Santé” (Paris, France) under the project “Viral metagenomics: a new tool for the surveillance of emerging infectious agents applied to blood safety”. |
| المصدر: | ISSN: 1567-1348. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases |
| الوصف: | International audience ; Since its first detection in 1979, dengue fever has been considered a major public health issue in the Lao People’s Democratic Republic (PDR). Dengue virus (DENV) serotype 1 was the cause of an epidemic in 2010–2011. Between 2012 and 2020, major outbreaks due successively to DENV-3, DENV-4 and recently DENV-2 have been recorded. However, DENV-1 still co-circulated in the country over this period. Here, we summarize epidemiological and molecular data of DENV-1 between 2016 and 2020 in the Lao PDR. Our data highlight the continuous circulation of DENV-1 in the country at levels ranging from 16% to 22% among serotyping tests. In addition, the phylogenetic analysis has revealed the circulation of DENV-1 genotype I at least since 2008 with a co-circulation of different clusters. Sequence data support independent DENV-1 introductions in the Lao PDR correlated with an active circulation of this serotype at the regional level in Southeast Asia. The maintenance of DENV-1 circulation over the last ten years supports a low level of immunity against this serotype within the Lao population. Thereby, the risk of a DENV-1 epidemic cannot be ruled out in the future, and this emphasizes the importance of maintaining an integrated surveillance approach to prevent major outbreaks. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34246798; pasteur-03713401; https://pasteur.hal.science/pasteur-03713401; PUBMED: 34246798 |
| DOI: | 10.1016/j.meegid.2021.104995 |
| الاتاحة: | https://pasteur.hal.science/pasteur-03713401 https://doi.org/10.1016/j.meegid.2021.104995 |
| رقم الانضمام: | edsbas.2C64568A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.meegid.2021.104995 |
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