التفاصيل البيبلوغرافية
| العنوان: |
DataSheet_1_Pre-Treatment Neutrophil Count as a Predictor of Antituberculosis Therapy Outcomes: A Multicenter Prospective Cohort Study.docx |
| المؤلفون: |
Anna Cristina C. Carvalho (11067591), Gustavo Amorim (4733925), Mayla G. M. Melo (11067594), Ana Karla A. Silveira (11067597), Pedro H. L. Vargas (11067600), Adriana S. R. Moreira (11067603), Michael S. Rocha (3144438), Alexandra B. Souza (10094056), María B. Arriaga (6807668), Mariana Araújo-Pereira (9413408), Marina C. Figueiredo (11067606), Betina Durovni (375250), José R. Lapa-e-Silva (11067609), Solange Cavalcante (671985), Valeria C. Rolla (6807671), Timothy R. Sterling (8955212), Marcelo Cordeiro-Santos (671984), Bruno B. Andrade (7205426), Elisangela C. Silva (3845152), Afrânio L. Kritski (6192386), the RePORT Brazil consortium (11067612) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, tuberculosis, neutrophils, treatment outcome, biomarker, neutrophil count |
| الوصف: |
Background Neutrophils have been associated with lung tissue damage in many diseases, including tuberculosis (TB). Whether neutrophil count can serve as a predictor of adverse treatment outcomes is unknown. Methods We prospectively assessed 936 patients (172 HIV-seropositive) with culture-confirmed pulmonary TB, enrolled in a multicenter prospective cohort study from different regions in Brazil, from June 2015 to June 2019, and were followed up to two years. TB patients had a baseline visit before treatment (month 0) and visits at month 2 and 6 (or at the end of TB treatment). Smear microscopy, and culture for Mycobacterium tuberculosis (MTB) were performed at TB diagnosis and during follow-up. Complete blood counts were measured at baseline. Treatment outcome was defined as either unfavorable (death, treatment failure or TB recurrence) or favorable (cure or treatment completion). We performed multivariable logistic regression, with propensity score regression adjustment, to estimate the association between neutrophil count with MTB culture result at month 2 and unfavorable treatment outcome. We used a propensity score adjustment instead of a fully adjusted regression model due to the relatively low number of outcomes. Results Among 682 patients who had MTB culture results at month 2, 40 (5.9%) had a positive result. After regression with propensity score adjustment, no significant association between baseline neutrophil count (10 3 /mm 3 ) and positive MTB culture at month 2 was found among either HIV-seronegative (OR = 1.06, 95% CI = [0.95;1.19] or HIV-seropositive patients (OR = 0.77, 95% CI = [0.51; 1.20]). Of 691 TB patients followed up for at least 18 months and up to 24 months, 635 (91.9%) were either cured or completed treatment, and 56 (8.1%) had an unfavorable treatment outcome. A multivariable regression with propensity score adjustment found an association between higher neutrophil count (10 3 /mm 3 ) at baseline and unfavorable outcome among HIV-seronegative patients [OR= 1.17 (95% CI= [1.06;1.30]). ... |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/DataSheet_1_Pre-Treatment_Neutrophil_Count_as_a_Predictor_of_Antituberculosis_Therapy_Outcomes_A_Multicenter_Prospective_Cohort_Study_docx/14900760 |
| DOI: |
10.3389/fimmu.2021.661934.s001 |
| الاتاحة: |
https://doi.org/10.3389/fimmu.2021.661934.s001 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.2C45469E |
| قاعدة البيانات: |
BASE |