Academic Journal
Concomitant medullary thyroid carcinoma with paraganglioma-like pattern and papillary thyroid carcinoma
| العنوان: | Concomitant medullary thyroid carcinoma with paraganglioma-like pattern and papillary thyroid carcinoma |
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| المؤلفون: | Greco C., Brigante G., Taliani E., Corrado S., Simoni M., Madeo B. |
| المساهمون: | Greco, C., Brigante, G., Taliani, E., Corrado, S., Simoni, M., Madeo, B. |
| سنة النشر: | 2019 |
| المجموعة: | Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) |
| مصطلحات موضوعية: | CT scan, Calcitonin, Carcinoembryonic antigen, Chromogranin A, Fine needle aspiration biopsy, Geriatric, Goitre, Goitre (multinodular), Histopathology, Immunohistochemistry, Italy, Lymph node dissection, Male, Medullary thyroid cancer, New disease or syndrome: presentations/diagnosis/management, November, Oncology, PET scan, Papillary thyroid cancer, Radioiodine, S-100 protein, TSH, Thyroglobulin, Thyroid, Thyroid transcription factor-1, Thyroid ultrasonography, Thyroidectomy, White, recombinant human TSH |
| Time: | 2019 |
| الوصف: | A 74-year-old man was referred to the Endocrinology Unit because of multinodular goiter. The dominant nodule (1.7 × 1.9 × 2.4 cm), at the medium-superior third of the left lobe, was inhomogeneously hypoechoic, with irregular margins, macrocalcifications and intranodular vascularization. Fine-needle aspiration biopsy (FNAB) was performed. The cytological diagnosis was TIR 2, benign, according to the 2013 Italian thyroid cytology classification system. Moderately high serum calcitonin (s-Ct) (61.5 pg/mL, n.r. 0–7.5) and normal CEA were detected. The Ct level in FNAB wash-out fluid (Ct-FNAB) was 1450 pg/mL. Based on s-Ct and Ct-FNAB levels, patient underwent total thyroidectomy. Macroscopically, a dominant circumscribed nodule of 2 ecm was described; the histological and immunohistochemical features identified medullary thyroid carcinoma (MTC) with paraganglioma (PG)-like pattern positive for Ct, CEA and chromogranin and negative for S-100 sustentacular cells (SC). Moreover, papillary carcinoma of 3 mm in the right lobe was also associated. No areas of hyperaccumulation of the tracer were documented at Ga68 PET/CT. No RET-proto-oncogene mutations were found. Post-surgery s-Ct levels were within normal range (4 pg/mL). Two years after thyroidectomy, the patient is still disease-free. We reported a case of sporadic and rare variant of MTC: this is the ninth described case of PG-like MTC. In this case, cytologically benign, the clinical suspicion arose from high Ct values at FNAB wash-out fluid. Even if clinical behavior of this variant seems indolent, additional studies are necessary to understand prognoses and predictive factors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31778356; info:eu-repo/semantics/altIdentifier/wos/WOS:000503730600001; volume:2019; issue:1; firstpage:1; lastpage:6; journal:ENDOCRINOLOGY, DIABETES & METABOLISM CASE REPORTS; http://hdl.handle.net/11380/1188842; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85076225780; https://edm.bioscientifica.com/downloadpdf/journals/edm/2019/1/EDM19-0094.xml |
| DOI: | 10.1530/EDM-19-0094 |
| الاتاحة: | http://hdl.handle.net/11380/1188842 https://doi.org/10.1530/EDM-19-0094 https://edm.bioscientifica.com/downloadpdf/journals/edm/2019/1/EDM19-0094.xml |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2BD6A603 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1530/EDM-19-0094 |
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