Academic Journal
Divergent Cellular Expression Patterns of PD-L1 and PD-L2 Proteins in Breast Cancer
| العنوان: | Divergent Cellular Expression Patterns of PD-L1 and PD-L2 Proteins in Breast Cancer |
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| المؤلفون: | Julie M. Jorns, Yunguang Sun, Sailaja Kamaraju, Yee Chung Cheng, Amanda Kong, Tina Yen, Caitlin R. Patten, Chandler S. Cortina, Christopher R. Chitambar, Hallgeir Rui, Lubna N. Chaudhary |
| المصدر: | Journal of Personalized Medicine, Vol 14, Iss 5, p 478 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | PD-L1, PD-L2, breast cancer, immunohistochemistry, immune checkpoint inhibition, Medicine |
| الوصف: | PD-L1 immunohistochemistry (IHC) has become an established method for predicting cancer response to targeted anti-PD1 immunotherapies, including breast cancer (BC). The alternative PD-1 ligand, PD-L2, remains understudied but may be a complementary predictive marker. Prospective analysis of 32 breast cancers revealed divergent expression patterns of PD-L1 and PD-L2. PD-L1-positivity was higher in immune cells than in cancer cells (median = 5.0% vs. 0.0%; p = 0.001), whereas PD-L2-positivity was higher in cancer cells than immune cells (median = 30% vs. 5.0%; p = 0.001). Percent positivity of PD-L1 and PD-L2 were not correlated, neither in cancer cells nor immune cells. Based on a cut-point of ≥1% positivity, ER+ tumors (n = 23) were frequently PD-L2-positive (73.9%), whereas only 40.9% were PD-L1-positive. These data suggest differential control of cellular PD-L1 and PD-L2 expression in BC and a potential role for PD-L2 IHC as a complementary marker to PD-L1 to improve selection of aggressive ER+ BC that may benefit from anti-PD-1 therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2075-4426 |
| Relation: | https://www.mdpi.com/2075-4426/14/5/478; https://doaj.org/toc/2075-4426; https://doaj.org/article/f2eb2167f6b5432094019dd19c7ec383 |
| DOI: | 10.3390/jpm14050478 |
| الاتاحة: | https://doi.org/10.3390/jpm14050478 https://doaj.org/article/f2eb2167f6b5432094019dd19c7ec383 |
| رقم الانضمام: | edsbas.2BC8081C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20754426 |
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| DOI: | 10.3390/jpm14050478 |