Academic Journal
Low sensitivity of rapid tests detecting anti-CoV-2 IgG and IgM in health care workers’ serum for COVID-19 screening
| العنوان: | Low sensitivity of rapid tests detecting anti-CoV-2 IgG and IgM in health care workers’ serum for COVID-19 screening |
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| المؤلفون: | Francesca Larese Filon, Antonio Purpuri, Davide Camata, Massimo Bovenzi, Francesca Rui, Federico Ronchese, Paola De Michieli, Alessandro Marcello, Monica Poggianella, Marco Confalonieri, Francesco Salton, Paola Confalonieri, Maurizio Ruscio, Anna Belgrano, Ludovica Segat, Pierlanfranco D’Agaro, Corrado Negro |
| المساهمون: | LARESE FILON, Francesca, Purpuri, Antonio, Camata, Davide, Bovenzi, Massimo, Rui, Francesca, Ronchese, Federico, DE MICHIELI, Paola, Marcello, Alessandro, Poggianella, Monica, Confalonieri, Marco, Salton, Francesco, Confalonieri, Paola, Ruscio, Maurizio, Belgrano, Anna, Segat, Ludovica, D'Agaro, Pierlanfranco, Negro, Corrado |
| سنة النشر: | 2021 |
| المجموعة: | Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) |
| مصطلحات موضوعية: | COVID-19, epidemiology, health care worker, diagnostic test, IgG antibody |
| الوصف: | Background: the sensitivity and specificity of a rapid antibody test were investigated for the screening of healthcare workers. Methods: the serum of 389 health care workers exposed to COVID-19 patients or with symptoms, were analysed. All workers underwent monthly the screening for SARS-CoV-2 with detection of viral RNA in nasopharyngeal swabs by RT-PCR. IgG antibody detection in serum was performed by Chemiluminescence Immunoassay (CLIA) and by the Rapid test (KHB diagnostic kit for SARS CoV-2 IgM/IgG antibody after a median of 7.6 weeks (25°-75° percentiles 6.6-11.5). Results: the rapid test resulted positive in 31/132 (23.5%), 16/135 (11.8%) and 0/122 cases in COVID-19 positive individuals, in those with only SARS-CoV-2 IgG antibodies and in those negative for both tests, respectively. Sensitivity was 17.6% (CI95% 13.2-22.7) and 23.5% (CI95% 16.5-31.6), and specificity was 100% (CI95% 97-100) and 100% (CI95% 97-100) considering Rapid test vs CLIA IgG or Rapid test vs SARS-CoV-2 positive RNA detection, respectively. Conclusion: the KHB Rapid test is not suitable for the screening of workers with previous COVID-19 infection. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34726663; info:eu-repo/semantics/altIdentifier/wos/WOS:000724898700001; volume:112; issue:5; firstpage:331; lastpage:339; numberofpages:9; journal:LA MEDICINA DEL LAVORO; http://hdl.handle.net/11368/2999276; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85119106384; https://www.mattioli1885journals.com/index.php/lamedicinadellavoro/article/view/11798 |
| DOI: | 10.23749/mdl.v112i5.11798 |
| الاتاحة: | http://hdl.handle.net/11368/2999276 https://doi.org/10.23749/mdl.v112i5.11798 https://www.mattioli1885journals.com/index.php/lamedicinadellavoro/article/view/11798 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2B9EC091 |
| قاعدة البيانات: | BASE |
| DOI: | 10.23749/mdl.v112i5.11798 |
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