Academic Journal
Acquired Treatment Resistance in a Patient with Metastatic PD-L1-Positive Breast Cancer and Germline BRCA1 Mutation
| العنوان: | Acquired Treatment Resistance in a Patient with Metastatic PD-L1-Positive Breast Cancer and Germline BRCA1 Mutation |
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| المؤلفون: | Kumeta, Toko, Yamaguchi, Kei, Hayami, Ryosuke, Arai, Kazumori, Tsuneizumi, Michiko, Matsunuma, Ryoichi |
| المصدر: | Case Reports in Oncology ; page 550-557 ; ISSN 1662-6575 |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 2023 |
| الوصف: | Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer associated with higher rates of relapse and mortality compared to other subtypes. Chemotherapy has been a mainstream treatment approach for TNBC due to the lack of therapeutic targets. Recent advances have led to the introduction of novel agents against specific patients with programmed death-ligand 1 (PD-L1)-positive TNBC who harbor germline BRCA mutations. However, some patients who respond to PD-L1 or poly (ADP-ribose) polymerase PARP inhibitors often develop resistance. Additionally, treatment strategies are more complicated for patients with PD-L1-positive TNBC and germline BRCA mutations. Here, we report a patient with metastatic PD-L1-positive TNBC who harbored a germline BRCA1 mutation. The patient sequentially received combination treatment regimens, including PD-L1 inhibitors with chemotherapy and the PARP inhibitor olaparib, acquiring resistance to the treatments in a couple of months. Further investigations are warranted to elucidate the mechanisms underlying resistance to PD-L1 antibodies and PARP inhibitors to improve treatment outcomes while preventing emergence of treatment resistance in patients with TNBC. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000530131 |
| الاتاحة: | http://dx.doi.org/10.1159/000530131 https://karger.com/cro/article-pdf/16/1/550/4013176/000530131.pdf |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ ; https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.2B8A9B6C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000530131 |
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