Academic Journal
Sequencing the Mouse Y Chromosome Reveals Convergent Gene Acquisition and Amplification on Both Sex Chromosomes
| العنوان: | Sequencing the Mouse Y Chromosome Reveals Convergent Gene Acquisition and Amplification on Both Sex Chromosomes |
|---|---|
| المؤلفون: | Pyntikova, Tatyana, Brown, Laura G., Graves, Tina, Minx, Patrick J., Fulton, Robert S., Kremitzki, Colin, Koutseva, Natalia, Mueller, Jacob L., Rozen, Steve, Hughes, Jennifer F., Owens, Elaine, Womack, James E., Murphy, William J., Cao, Qing, de Jong, Pieter, Warren, Wesley C., Wilson, Richard K., Skaletsky, Helen, Soh, Ying Qi Shirleen, Alfoldi, Jessica E., Page, David C |
| المساهمون: | Massachusetts Institute of Technology. Department of Biology, Whitehead Institute for Biomedical Research, Soh, Ying Qi Shirleen, Alfoldi, Jessica E., Page, David C |
| المصدر: | PMC |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2014 |
| المجموعة: | DSpace@MIT (Massachusetts Institute of Technology) |
| الوصف: | We sequenced the MSY (male-specific region of the Y chromosome) of the C57BL/6J strain of the laboratory mouse Mus musculus. In contrast to theories that Y chromosomes are heterochromatic and gene poor, the mouse MSY is 99.9% euchromatic and contains about 700 protein-coding genes. Only 2% of the MSY derives from the ancestral autosomes that gave rise to the mammalian sex chromosomes. Instead, all but 45 of the MSY’s genes belong to three acquired, massively amplified gene families that have no homologs on primate MSYs but do have acquired, amplified homologs on the mouse X chromosome. The complete mouse MSY sequence brings to light dramatic forces in sex chromosome evolution: lineage-specific convergent acquisition and amplification of X-Y gene families, possibly fueled by antagonism between acquired X-Y homologs. The mouse MSY sequence presents opportunities for experimental studies of a sex-specific chromosome in its entirety, in a genetically tractable model organism. ; National Institutes of Health (U.S.) ; Howard Hughes Medical Institute |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1097-4172 0092-8674 |
| Relation: | http://dx.doi.org/10.1016/j.cell.2014.09.052; Cell; http://hdl.handle.net/1721.1/106554; Naba, Alexandra, Karl R. Clauser, and Richard O. Hynes. “Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis.” Journal of Visualized Experiments 101 (2015): n. pag.; orcid:0000-0001-9920-3411 |
| الاتاحة: | http://hdl.handle.net/1721.1/106554 |
| Rights: | Creative Commons Attribution-NonCommercial-NoDerivs License ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.2B5030E4 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10974172 00928674 |
|---|