Academic Journal
Transmissible cancer influences immune gene expression in an endangered marsupial, the Tasmanian devil (Sarcophilus harrisii).
| العنوان: | Transmissible cancer influences immune gene expression in an endangered marsupial, the Tasmanian devil (Sarcophilus harrisii). |
|---|---|
| المؤلفون: | Raven, Nynke, Klaassen, Marcel, Madsen, Thomas, Thomas, Frédéric, Hamede, Rodrigo, Ujvari, Beata |
| المساهمون: | Deakin University Burwood, Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM), Centre de Recherches Ecologiques et Evolutives sur le Cancer (MIVEGEC-CREEC), Processus Écologiques et Évolutifs au sein des Communautés (PEEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM)-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM), Deakin University Waurn Ponds, ANR TRANSCAN, Grant/Award Number: ANR- 18- CE35- 0009, Centre National de la Recherche Scientifique, ARC Linkage, Grant/Award Number: LP170101105, Deakin SEBE, Grant/Award Number: RGS_2019, ARC Decra, Grant/Award Number: DE170101116, The University of Tasmania Foundation, Deakin CIE, Holsworth Wildlife Research Endowment, ANR-18-CE35-0009,TRANSCAN,ECOLOGIE ET EVOLUTION DES CANCERS TRANSMISSIBLES(2018) |
| المصدر: | ISSN: 0962-1083. |
| بيانات النشر: | HAL CCSD Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | Cancer, Conservation physiology, Host-parasite interactions, Immune system, Life history trade-off, MESH: Animals, Wild, MESH: Facial Neoplasms, MESH: Gene Expression, MESH: Marsupialia, MESH: Seasons, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity |
| الوصف: | International audience ; Understanding the effects of wildlife diseases on populations requires insight into local environmental conditions, host defence mechanisms, host life-history trade-offs, pathogen population dynamics, and their interactions. The survival of Tasmanian devils (Sarcophilus harrisii) is challenged by a novel, fitness limiting pathogen, Tasmanian devil facial tumour disease (DFTD), a clonally transmissible, contagious cancer. In order to understand the devils' capacity to respond to DFTD, it is crucial to gain information on factors influencing the devils' immune system. By using RT-qPCR, we investigated how DFTD infection in association with intrinsic (sex and age) and environmental (season) factors influences the expression of 10 immune genes in Tasmanian devil blood. Our study showed that the expression of immune genes (both innate and adaptive) differed across seasons, a pattern that was altered when infected with DFTD. The expression of immunogbulins IgE and IgM:IgG showed downregulation in colder months in DFTD infected animals. We also observed strong positive association between the expression of an innate immune gene, CD16, and DFTD infection. Our results demonstrate that sampling across seasons, age groups and environmental conditions are beneficial when deciphering the complex ecoevolutionary interactions of not only conventional host-parasite systems, but also of host and diseases with high mortality rates, such as transmissible cancers. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/35202488; PUBMED: 35202488; PUBMEDCENTRAL: PMC9310804; WOS: 000768912600001 |
| DOI: | 10.1111/mec.16408 |
| الاتاحة: | https://hal.science/hal-04116964 https://hal.science/hal-04116964v1/document https://hal.science/hal-04116964v1/file/Molecular%20Ecology%202022%20Tasmanian%20Devil.pdf https://doi.org/10.1111/mec.16408 |
| Rights: | http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.2B3070FD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/mec.16408 |
|---|