Academic Journal
Compartmentalized Polyampholyte Microgels by Depletion Flocculation and Coacervation of Nanogels in Emulsion Droplets
| العنوان: | Compartmentalized Polyampholyte Microgels by Depletion Flocculation and Coacervation of Nanogels in Emulsion Droplets |
|---|---|
| المؤلفون: | Mathews, Hannah F., Pieper, Maria I., Jung, Se-Hyeong, Pich, Andrij |
| المصدر: | Mathews , H F , Pieper , M I , Jung , S-H & Pich , A 2023 , ' Compartmentalized Polyampholyte Microgels by Depletion Flocculation and Coacervation of Nanogels in Emulsion Droplets ' , Angewandte Chemie-International Edition , vol. 62 , no. 36 , e202304908 . https://doi.org/10.1002/anie.202304908 |
| سنة النشر: | 2023 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | Colloids, Cooperative Effects, Janus-like Phase-Separation, Polyampholyte, Responsive Materials, INDUCED PHASE-SEPARATION, DRUG-DELIVERY, IONIC-STRENGTH, RESPONSIVE MICROGELS, FUNCTIONAL MICROGELS, CONTROLLED-RELEASE, N-ISOPROPYLACRYLAMIDE, PH, TEMPERATURE, MICROPARTICLES |
| الوصف: | In pH-responsive drug carriers, the distribution of charges has been proven to affect delivery efficiency but is difficult to control and verify. Herein, we fabricate polyampholyte nanogel-in-microgel colloids (NiM-C) and show that the arrangement of the nanogels (NG) can easily be manipulated by adapting synthesis conditions. Positively and negatively charged pH-responsive NG are synthesized by precipitation polymerization and labelled with different fluorescent dyes. The obtained NG are integrated into microgel (MG) networks by subsequent inverse emulsion polymerization in droplet-based microfluidics. By confocal laser scanning microscopy (CLSM), we verify that depending on NG concentration, pH value and ionic strength, NiM-C with different NG arrangements are obtained, including Janus-like phase-separation of NG, statistical distribution of NG, and core-shell arrangements. Our approach is a major step towards uptake and release of oppositely charged (drug) molecules. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://cris.maastrichtuniversity.nl/en/publications/971aaef1-4b62-49b5-bb6f-5afae66d3805 |
| DOI: | 10.1002/anie.202304908 |
| الاتاحة: | https://cris.maastrichtuniversity.nl/en/publications/971aaef1-4b62-49b5-bb6f-5afae66d3805 https://doi.org/10.1002/anie.202304908 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2AF5482D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/anie.202304908 |
|---|