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Simian virus 40 sequences in human lymphoblastoid B-cell lines

التفاصيل البيبلوغرافية
العنوان: Simian virus 40 sequences in human lymphoblastoid B-cell lines
المؤلفون: Dolcetti R, Martini F, Quaia M, Gloghini A, Vignocchi B, Cariati R, Martinelli M, Carbone A, Boiocchi M, Tognon M
المساهمون: Dolcetti R, Martini F, Quaia M, Gloghini A, Vignocchi B, Cariati R, Martinelli M, Carbone A, Boiocchi M, Tognon M
سنة النشر: 2003
المجموعة: IRIS Università degli Studi di Bologna (CRIS - Current Research Information System)
مصطلحات موضوعية: SV40, lymphoblastoid B-cell lines
الوصف: Human Epstein-Barr virus-immortalized lymphoblastoid B-cell lines tested positive by PCR for simian virus 40 (SV40) DNA (22 of 42 cell lines, 52.3%). B lymphocytes or tissues from which B-cell lines derived were also SV40 positive. In situ hybridization showed that SV40 DNA was present in the nucleus of a small fraction (1/250) of cells. SV40 T-antigen mRNA was detected by reverse transcription-PCR. Lymphoblastoid B-cell lines (n = 4) infected with SV40 remained SV40 positive for 4 to 6 months. SV40-positive B-cell lines were more tumorigenic in SCID mice than were SV40-negative cell lines (4 of 5 [80%] SV40-positive cell lines versus 2 of 4 [50%] SV40-negative cell lines). These results suggest that SV40 may play a role in the early phases of human lymphomagenesis.
نوع الوثيقة: article in journal/newspaper
وصف الملف: STAMPA
اللغة: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/12502874; info:eu-repo/semantics/altIdentifier/wos/WOS:000180166600078; volume:77; issue:2; firstpage:1595; lastpage:1597; numberofpages:3; journal:JOURNAL OF VIROLOGY; https://hdl.handle.net/11585/917418; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0037225638
DOI: 10.1128/JVI.77.2.1595-1597.2003
الاتاحة: https://hdl.handle.net/11585/917418
https://doi.org/10.1128/JVI.77.2.1595-1597.2003
رقم الانضمام: edsbas.2A76FDC2
قاعدة البيانات: BASE
الوصف
DOI:10.1128/JVI.77.2.1595-1597.2003