Academic Journal
Intraoperative High Fraction of Inspiratory Oxygen is Independently Associated with Worse Outcome After Living‐Donor Liver Transplantation: A Retrospective Study
| العنوان: | Intraoperative High Fraction of Inspiratory Oxygen is Independently Associated with Worse Outcome After Living‐Donor Liver Transplantation: A Retrospective Study |
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| المؤلفون: | Miyachi, Yosuke, Kaido, Toshimi, Hirata, Masaaki, Sharshar, Mohamed, Macshut, Mahmoud, Yao, Siyuan, Kamo, Naoko, Kai, Shinichi, Yagi, Shintaro, Uemoto, Shinji |
| المصدر: | World Journal of Surgery ; volume 46, issue 7, page 1776-1787 ; ISSN 0364-2313 1432-2323 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background Ischemia and reperfusion injury is an important factor that determines graft function after liver transplantation, and oxygen plays a crucial role in this process. However, the relationship between the intraoperative high fraction of inspiratory oxygen (FiO 2 ) and living‐donor‐liver‐transplantation (LDLT) outcome remains unclear. Patients and Methods A total of 199 primary adult‐to‐adult LDLT cases in Kyoto University Hospital between January 2010 and December 2017 were enrolled in this study. The intraoperative FiO 2 was averaged using the total amount of intraoperative oxygen and air and defined as the calculated FiO 2 (cFiO 2 ). The cutoff value of cFiO 2 was set at 0.5. Results Between the cFiO 2 <0.5 ( n = 156) and ≥0.5 group ( n = 43), preoperative recipients’ background, donor factors, and intraoperative parameters were almost comparable. Postoperatively, the cFiO 2 ≥0.5 group showed a higher early allograft dysfunction (EAD) rate ( P = 0.049) and worse overall graft survival ( P = 0.036) than the cFiO 2 <0.5 group. Although the cFiO 2 ≥0.5 was not an independent risk factor for EAD in multivariable analysis (OR 2.038, 95%CI 0.992–4.186, P = 0.053), it was an independent risk factor for overall graft survival after LDLT (HR 1.897, 95%CI 1.007–3.432, P = 0.048). Conclusion The results of this study suggest that intraoperative high FiO 2 may be associated with worse graft survival after LDLT. Avoiding higher intraoperative FiO 2 may be beneficial for LDLT recipients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1007/s00268-022-06544-7 |
| DOI: | 10.1007/s00268-022-06544-7.pdf |
| DOI: | 10.1007/s00268-022-06544-7/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1007/s00268-022-06544-7 https://link.springer.com/content/pdf/10.1007/s00268-022-06544-7.pdf https://link.springer.com/article/10.1007/s00268-022-06544-7/fulltext.html https://onlinelibrary.wiley.com/doi/pdf/10.1007/s00268-022-06544-7 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor ; https://www.springer.com/tdm ; https://www.springer.com/tdm |
| رقم الانضمام: | edsbas.29F53433 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00268-022-06544-7 |
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