Academic Journal

Immunogenicity of a single dose mRNA vaccine in SARS-CoV-2 exposed subjects: A systematic review

التفاصيل البيبلوغرافية
العنوان: Immunogenicity of a single dose mRNA vaccine in SARS-CoV-2 exposed subjects: A systematic review
المؤلفون: Singh, Jagtar, Thakur, Seema
المصدر: South East Asia Journal of Medical Sciences; Volume 6, Issue 2; 2022; 1-13 ; 2522-7165 ; 2520-7342
بيانات النشر: Little Bay Publishers
سنة النشر: 2022
المجموعة: South East Asia Journal of Medical Sciences
مصطلحات موضوعية: Immunity, SARS-CoV-2, Vaccination, COVID-19, mRNA
الوصف: Background: The novel coronavirus is quickly spreading and mutating, putting the public health and lifestyle in shambles. The development and approval of mRNA vaccines came up as a breakthrough. The breadth of immune response after a single-dose vaccination in the already infected population is discovered for understanding the hybrid immunity and side effects associated with second dose. Administering a single-dose vaccine to the seropositive population can spare the doses for the population at higher risk. Methods: PubMed, Web of Science, Google scholar, medRxiv and Cochrane library were explored to extract the original data on the efficacy of single-dose mRNA vaccines in seropositive subjects. The Cochrane risk of bias tool was used to assess the risk of bias in the studies. Results: 6 studies evaluating the immunogenicity of single-dose mRNA vaccine were incorporated along with some observational studies and literature. These studies present promising evidence for administering only single-dose mRNA vaccine in seropositive subjects, providing biphasic immune response of higher breadth and duration. Limitations: Most studies had a small sample size, did not correlate the results with higher age groups, with potential risk factors and the percentage of individuals who contracted breakthrough infections. Conclusions: Single-dose mRNA vaccine can be immunogenic and protective enough for already seropositive population by increasing the number of Spike protein-specific memory B-cells. Vaccination schedules based on existing anti-body titers in such individuals can spare doses for vulnerable groups, especially when there is limited production and supply of vaccines worldwide.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf; text/xml
اللغة: English
Relation: https://littlebaypublishers.com/index.php/seajournalms/article/view/85/97; https://littlebaypublishers.com/index.php/seajournalms/article/view/85/115; https://littlebaypublishers.com/index.php/seajournalms/article/view/85/116; https://littlebaypublishers.com/index.php/seajournalms/article/view/85
الاتاحة: https://littlebaypublishers.com/index.php/seajournalms/article/view/85
Rights: Copyright (c) 2022 Jagtar Singh, Seema Thakur ; https://creativecommons.org/licenses/by-nc-sa/4.0
رقم الانضمام: edsbas.29E82D2A
قاعدة البيانات: BASE