التفاصيل البيبلوغرافية
العنوان: |
Immunogenicity of a single dose mRNA vaccine in SARS-CoV-2 exposed subjects: A systematic review |
المؤلفون: |
Singh, Jagtar, Thakur, Seema |
المصدر: |
South East Asia Journal of Medical Sciences; Volume 6, Issue 2; 2022; 1-13 ; 2522-7165 ; 2520-7342 |
بيانات النشر: |
Little Bay Publishers |
سنة النشر: |
2022 |
المجموعة: |
South East Asia Journal of Medical Sciences |
مصطلحات موضوعية: |
Immunity, SARS-CoV-2, Vaccination, COVID-19, mRNA |
الوصف: |
Background: The novel coronavirus is quickly spreading and mutating, putting the public health and lifestyle in shambles. The development and approval of mRNA vaccines came up as a breakthrough. The breadth of immune response after a single-dose vaccination in the already infected population is discovered for understanding the hybrid immunity and side effects associated with second dose. Administering a single-dose vaccine to the seropositive population can spare the doses for the population at higher risk. Methods: PubMed, Web of Science, Google scholar, medRxiv and Cochrane library were explored to extract the original data on the efficacy of single-dose mRNA vaccines in seropositive subjects. The Cochrane risk of bias tool was used to assess the risk of bias in the studies. Results: 6 studies evaluating the immunogenicity of single-dose mRNA vaccine were incorporated along with some observational studies and literature. These studies present promising evidence for administering only single-dose mRNA vaccine in seropositive subjects, providing biphasic immune response of higher breadth and duration. Limitations: Most studies had a small sample size, did not correlate the results with higher age groups, with potential risk factors and the percentage of individuals who contracted breakthrough infections. Conclusions: Single-dose mRNA vaccine can be immunogenic and protective enough for already seropositive population by increasing the number of Spike protein-specific memory B-cells. Vaccination schedules based on existing anti-body titers in such individuals can spare doses for vulnerable groups, especially when there is limited production and supply of vaccines worldwide. |
نوع الوثيقة: |
article in journal/newspaper |
وصف الملف: |
application/pdf; text/xml |
اللغة: |
English |
Relation: |
https://littlebaypublishers.com/index.php/seajournalms/article/view/85/97; https://littlebaypublishers.com/index.php/seajournalms/article/view/85/115; https://littlebaypublishers.com/index.php/seajournalms/article/view/85/116; https://littlebaypublishers.com/index.php/seajournalms/article/view/85 |
الاتاحة: |
https://littlebaypublishers.com/index.php/seajournalms/article/view/85 |
Rights: |
Copyright (c) 2022 Jagtar Singh, Seema Thakur ; https://creativecommons.org/licenses/by-nc-sa/4.0 |
رقم الانضمام: |
edsbas.29E82D2A |
قاعدة البيانات: |
BASE |