Academic Journal
SARS-CoV-2 Psychiatric Sequelae: A Review of Neuroendocrine Mechanisms and Therapeutic Strategies
| العنوان: | SARS-CoV-2 Psychiatric Sequelae: A Review of Neuroendocrine Mechanisms and Therapeutic Strategies |
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| المؤلفون: | Hornick, Mary G, Olson, Margaret E, Jadhav, Arun L |
| المصدر: | International Journal of Neuropsychopharmacology ; volume 25, issue 1, page 1-12 ; ISSN 1461-1457 1469-5111 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2021 |
| الوصف: | From the earliest days of the coronavirus disease 2019 (COVID-19) pandemic, there have been reports of significant neurological and psychological symptoms following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. This narrative review is designed to examine the potential psychoneuroendocrine pathogenic mechanisms by which SARS-CoV-2 elicits psychiatric sequelae as well as to posit potential pharmacologic strategies to address and reverse these pathologies. Following a brief overview of neurological and psychological sequelae from previous viral pandemics, we address mechanisms by which SARS-CoV-2 could enter or otherwise elicit changes in the CNS. We then examine the hypothesis that COVID-19–induced psychiatric disorders result from challenges to the neuroendocrine system, in particular the hypothalamic-pituitary-adrenal stress axis and monoamine synthesis, physiological mechanisms that are only further enhanced by the pandemic-induced social environment of fear, isolation, and socioeconomic pressure. Finally, we evaluate several FDA-approved therapeutics in the context of COVID-19–induced psychoneuroendocrine disorders. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ijnp/pyab069 |
| DOI: | 10.1093/ijnp/pyab069/41028573/pyab069.pdf |
| الاتاحة: | https://doi.org/10.1093/ijnp/pyab069 http://academic.oup.com/ijnp/advance-article-pdf/doi/10.1093/ijnp/pyab069/41028573/pyab069.pdf https://academic.oup.com/ijnp/article-pdf/25/1/1/42165265/pyab069.pdf |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.29E613DB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ijnp/pyab069 |
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