Academic Journal
Plasma homocysteine levels and genetic polymorphisms in folate metablism are associated with breast cancer risk in chinese women
| العنوان: | Plasma homocysteine levels and genetic polymorphisms in folate metablism are associated with breast cancer risk in chinese women |
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| المؤلفون: | Wu, Xiayu, Zou, Tianning, Cao, Neng, Ni, Juan, Xu, Weijiang, Zhou, Tao, Wang, Xu |
| المصدر: | Hereditary Cancer in Clinical Practice ; volume 12, issue 1 ; ISSN 1897-4287 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2014 |
| الوصف: | Background Folate plays a pivotal role in DNA synthesis, repair, methylation and homocysteine (Hcy) metabolism. Therefore, alterations in the folate-mediated one-carbon metabolism may lead to abnormal methylation proliferation, increases of tumor/neoplasia and vein thrombosis/cardiovascular risk. The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism. Therefore, we investigated whether the genetic variants of the SHMT, MS, MTRR and CBS g ene can affect plasma Hcy levels and are associated with breast cancer risk. Methods Genotyping was performed by PCR-RFLP method. Plasma Hcy levels were measured by the fluorescence polarization immunoassay on samples of 96 cases and 85 controls. Results (a) The SHMT 1420 T, MS 2756G, MTRR 66G allele frequency distribution showed significant difference between case and controls (p < 0.01 ~ 0.05). (b) The concentration of plasma Hcy levels of SHMT 1420TT was significantly lower than that of the wild type, while the plasma Hcy levels of MS 2756GG , CBS 699TT/1080TT significantly higher than that of the wild type both in case and controls. The plasma Hcy levels of MTRR 66GG was significantly higher than that of wild type in cases. The plasma Hcy levels of the same genotype in cases were significantly higher than those of controls except SHMT 1420CC, MS 2756AA, MTRR 66GG ; (c) Multivariate Logistic regression analysis showed that SHMT C1420T (OR = 0.527, 95% CI = 0.55 ~ 1.24), MS A2756G (OR = 2.32, 95% CI = 0.29 ~ 0.82), MTRR A66G (OR = 1.84, 95% CI = 0.25 ~ 1.66) polymorphism is significantly associated with breast cancer risk. And elevated plasma Hcy levels were significantly linked to increased risk of breast cancer (adjusted OR = 4.45, 95% CI = 1.89-6.24 for the highest tertile as compared with the lowest tertile). Conclusions The current study results seem to suggest a possibility that S HMT C1420T mutation may be ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/1897-4287-12-2 |
| DOI: | 10.1186/1897-4287-12-2.pdf |
| DOI: | 10.1186/1897-4287-12-2/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/1897-4287-12-2 http://link.springer.com/content/pdf/10.1186/1897-4287-12-2.pdf http://link.springer.com/article/10.1186/1897-4287-12-2/fulltext.html http://link.springer.com/content/pdf/10.1186/1897-4287-12-2 https://link.springer.com/content/pdf/10.1186/1897-4287-12-2.pdf |
| Rights: | http://www.springer.com/tdm |
| رقم الانضمام: | edsbas.29D7811D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/1897-4287-12-2 |
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