التفاصيل البيبلوغرافية
| العنوان: |
Heat Shock Proteins 90 kDa: Immunomodulators and Adjuvants in Vaccine Design Against Infectious Diseases |
| المؤلفون: |
Corigliano, Mariana Georgina, Sander, Valeria Analia, Sánchez López, Edwin Fernando, Ramos Duarte, Víctor Andrés, Mendoza Morales, Luisa Fernanda, Angel, Sergio Oscar, Clemente, Marina |
| بيانات النشر: |
Frontiers Media |
| المجموعة: |
CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| مصطلحات موضوعية: |
CARRIER, CHAPERONES, CROSS-PRESENTATION, GP96, GRP94, HSP90, MHC CLASS I, RE-PRESENTATION, https://purl.org/becyt/ford/3.4, https://purl.org/becyt/ford/3 |
| الوصف: |
Heat shock proteins 90 kDa (Hsp90s) were originally identified as stress-responsive proteins and described to participate in several homeostatic processes. Additionally, extracellular Hsp90s have the ability to bind to surface receptors and activate cellular functions related to immune response (cytokine secretion, cell maturation, and antigen presentation), making them very attractive to be studied as immunomodulators. In this context, Hsp90s are proposed as new adjuvants in the design of novel vaccine formulations that require the induction of a cell-mediated immune response to prevent infectious diseases. In this review, we summarized the adjuvant properties of Hsp90s when they are either alone, complexed, or fused to a peptide to add light to the knowledge of Hsp90s as carriers and adjuvants in the design of vaccines against infectious diseases. Besides, we also discuss the mechanisms by which Hsp90s activate and modulate professional antigen-presenting cells. ; Fil: Corigliano, Mariana Georgina. Universidad Nacional de San Martin. Instituto Tecnologico de Chascomus. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - la Plata. Instituto Tecnologico de Chascomus.; Argentina ; Fil: Sander, Valeria Analia. Universidad Nacional de San Martin. Instituto Tecnologico de Chascomus. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - la Plata. Instituto Tecnologico de Chascomus.; Argentina ; Fil: Sánchez López, Edwin Fernando. Universidad Nacional de San Martin. Instituto Tecnologico de Chascomus. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - la Plata. Instituto Tecnologico de Chascomus.; Argentina ; Fil: Ramos Duarte, Víctor Andrés. Universidad Nacional de San Martin. Instituto Tecnologico de Chascomus. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - la Plata. Instituto Tecnologico de Chascomus.; Argentina ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
2296-4185 |
| Relation: |
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fbioe.2020.622186/full; http://hdl.handle.net/11336/164138; Corigliano, Mariana Georgina; Sander, Valeria Analia; Sánchez López, Edwin Fernando; Ramos Duarte, Víctor Andrés; Mendoza Morales, Luisa Fernanda; et al.; Heat Shock Proteins 90 kDa: Immunomodulators and Adjuvants in Vaccine Design Against Infectious Diseases; Frontiers Media; Frontiers in Bioengineering and Biotechnology; 8; 622186; 1-2021; 1-19; CONICET Digital; CONICET |
| الاتاحة: |
http://hdl.handle.net/11336/164138 |
| Rights: |
info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| رقم الانضمام: |
edsbas.29825FA4 |
| قاعدة البيانات: |
BASE |