Academic Journal

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

التفاصيل البيبلوغرافية
العنوان: GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
المؤلفون: Franceschini N., Giambartolomei C., de Vries P. S., Finan C., Bis J. C., Huntley R. P., Lovering R. C., Tajuddin S. M., Winkler T. W., Graff M., Kavousi M., Dale C., Smith A. V., Hofer E., van Leeuwen E. M., Nolte I. M., Lu L., Scholz M., Sargurupremraj M., Pitkanen N., Franzen O., Joshi P. K., Noordam R., Marioni R. E., Hwang S. -J., Musani S. K., Schminke U., Palmas W., Isaacs A., Correa A., Zonderman A. B., Hofman A., Teumer A., Cox A. J., Uitterlinden A. G., Wong A., Smit A. J., Newman A. B., Britton A., Ruusalepp A., Sennblad B., Hedblad B., Pasaniuc B., Penninx B. W., Langefeld C. D., Wassel C. L., Tzourio C., Fava C., Baldassarre D., O'Leary D. H., Teupser D., Kuh D., Tremoli E., Mannarino E., Grossi E., Boerwinkle E., Schadt E. E., Ingelsson E., Veglia F., Rivadeneira F., Beutner F., Chauhan G., Heiss G., Snieder H., Campbell H., Volzke H., Markus H. S., Deary I. J., Jukema J. W., de Graaf J., Price J., Pott J., Hopewell J. C., Liang J., Thiery J., Engmann J., Gertow K., Rice K., Taylor K. D., Dhana K., Kiemeney L. A. L. M., Lind L., Raffield L. M., Launer L. J., Holdt L. M., Dorr M., Dichgans M., Traylor M., Sitzer M., Kumari M., Kivimaki M., Nalls M. A., Melander O., Raitakari O., Franco O. H., Rueda-Ochoa O. L., Roussos P., Whincup P. H., Amouyel P., Giral P., Anugu P., Wong Q., Malik R., Rauramaa R., Burkhardt R., Hardy R., Schmidt R., de Mutsert R., Morris R. W., Strawbridge R. J., Wannamethee S. G., Hagg S., Shah S., McLachlan S., Trompet S., Seshadri S., Kurl S., Heckbert S. R., Ring S., Harris T. B., Lehtimaki T., Galesloot T. E., Shah T., de Faire U., Plagnol V., Rosamond W. D., Post W., Zhu X., Zhang X., Guo X., Saba Y., Okada Y., Mishra A., Rutten-Jacobs L., Giese A. -K., van der Laan S. W., Gretarsdottir S., Anderson C. D., Chong M., Adams H. H. H., Ago T., Almgren P., Ay H., Bartz T. M., Benavente O. R., Bevan S., Boncoraglio G. B., Brown R. D., Butterworth A. S., Carrera C., Carty C. L., Chasman D. I., Chen W. -M., Cole J. W., Cotlarciuc I., Cruchaga C., Danesh J., de Bakker P. I. W., DeStefano A. L., den Hoed M., Duan Q., Engelter S. T., Falcone G. J., Gottesman R. F., Grewal R. P., Gustafsson S., Haessler J., Hassan A., Havulinna A. S., Holliday E. G., Howard G., Hsu F. -C., Hyacinth H. I., Ikram M. A., Irvin M. R., Jian X., Jimenez-Conde J., Johnson J. A., Kanai M., Keene K. L., Kissela B. M., Kleindorfer D. O., Kooperberg C., Kubo M., Lange L., Langenberg C., Lee J. -M., Lemmens R., Leys D., Lewis C. M., Lin W. -Y., Lindgren A. G., Lorentzen E., Magnusson P. K., Maguire J., Manichaikul A., McArdle P. F., Meschia J. F., Mosley T. H., Ninomiya T., O'Donnell M. J., Pulit S. L., Rannikmae K., Reiner A. P., Rexrode K. M., Rich S. S., Ridker P. M., Rost N. S., Rothwell P. M., Rundek T., Sacco R. L., Sakaue S., Sale M. M., Salomaa V., Sapkota B. R., Schmidt C. O., Sharma P., Slowik A., Sudlow C. L. M., Tanislav C., Tatlisumak T., Thijs V. N. S., Thorleifsson G., Thorsteinsdottir U., Tiedt S., Walters M., Wareham N. J., Wassertheil-Smoller S., Wiggins K. L., Yang Q., Yusuf S., Pastinen T., Koplev S., Codoni V., Civelek M., Smith N., Tregouet D. A., Christophersen I. E., Roselli C., Lubitz S. A., Ellinor P. T., Tai E. S., Kooner J. S., Kato N., He J., van der Harst P., Elliott P., Chambers J. C., Takeuchi F., Johnson A. D., Sanghera D. K., Jern C., Strbian D., Fernandez-Cadenas I., Longstreth W. T., Rolfs A., Hata J., Woo D., Rosand J., Pare G., Saleheen D., Stefansson K., Worrall B. B., Kittner S. J., Howson J. M. M., Kamatani Y., Dehghan A., Seldenrijk A., Morrison A. C., Hamsten A., Psaty B. M., van Duijn C. M., Lawlor D. A., Mook-Kanamori D. O., Bowden D. W., Schmidt H., Wilson J. F., Wilson J. G., Rotter J. I., Wardlaw J. M., Deanfield J., Halcox J., Lyytikainen L. -P., Loeffler M., Evans M. K., Debette S., Humphries S. E., Volker U., Gudnason V., Hingorani A. D., Bjorkegren J. L. M., Casas J. P., O'Donnell C. J.
المساهمون: N. Franceschini, C. Giambartolomei, P.S. de Vrie, C. Finan, J.C. Bi, R.P. Huntley, R.C. Lovering, S.M. Tajuddin, T.W. Winkler, M. Graff, M. Kavousi, C. Dale, A.V. Smith, E. Hofer, E.M. van Leeuwen, I.M. Nolte, L. Lu, M. Scholz, M. Sargurupremraj, N. Pitkanen, O. Franzen, P.K. Joshi, R. Noordam, R.E. Marioni, S.-. Hwang, S.K. Musani, U. Schminke, W. Palma, A. Isaac, A. Correa, A.B. Zonderman, A. Hofman, A. Teumer, A.J. Cox, A.G. Uitterlinden, A. Wong, A.J. Smit, A.B. Newman, A. Britton, A. Ruusalepp, B. Sennblad, B. Hedblad, B. Pasaniuc, B.W. Penninx, C.D. Langefeld, C.L. Wassel, C. Tzourio, C. Fava, D. Baldassarre, D.H. O'Leary, D. Teupser, D. Kuh, E. Tremoli, E. Mannarino, E. Grossi, E. Boerwinkle, E.E. Schadt, E. Ingelsson, F. Veglia, F. Rivadeneira, F. Beutner, G. Chauhan, G. Hei, H. Snieder, H. Campbell, H. Volzke, H.S. Marku, I.J. Deary, J.W. Jukema, J. de Graaf, J. Price, J. Pott, J.C. Hopewell, J. Liang, J. Thiery, J. Engmann, K. Gertow, K. Rice, K.D. Taylor, K. Dhana, L.A.L.M. Kiemeney, L. Lind, L.M. Raffield, L.J. Launer, L.M. Holdt, M. Dorr, M. Dichgan, M. Traylor, M. Sitzer, M. Kumari, M. Kivimaki, M.A. Nall, O. Melander, O. Raitakari, O.H. Franco, O.L. Rueda-Ochoa, P. Rousso, P.H. Whincup, P. Amouyel, P. Giral
بيانات النشر: Nature
سنة النشر: 2018
المجموعة: The University of Milan: Archivio Istituzionale della Ricerca (AIR)
مصطلحات موضوعية: Settore BIO/14 - Farmacologia
الوصف: Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans.
نوع الوثيقة: article in journal/newspaper
اللغة: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/30510157; info:eu-repo/semantics/altIdentifier/wos/WOS:000451873600017; volume:9; issue:1; firstpage:1; lastpage:14; numberofpages:14; journal:NATURE COMMUNICATIONS; http://hdl.handle.net/2434/607001; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85057617727
DOI: 10.1038/s41467-018-07340-5
الاتاحة: http://hdl.handle.net/2434/607001
https://doi.org/10.1038/s41467-018-07340-5
Rights: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.293B4E4E
قاعدة البيانات: BASE
الوصف
DOI:10.1038/s41467-018-07340-5