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Loss of Nrx-IV and Nrg adhesions in NSC lineages during development results in locomotor hyperactivity in the adults.
| العنوان: | Loss of Nrx-IV and Nrg adhesions in NSC lineages during development results in locomotor hyperactivity in the adults. |
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| المؤلفون: | Agata Banach-Latapy, Vincent Rincheval, David Briand, Isabelle Guénal, Pauline Spéder |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Cell Biology, Neuroscience, Developmental Biology, Cancer, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, stem cell population, shapes adult behaviour, div >< p, defined cellular microenvironment, individual stem cell, related cells regardless, neural stem cells, altered cg network, individual encasing, also altered, wrapper exists, weaker interaction, stereotypic structure, resulting adults, nsc lineages, newborn neurons, neuroglian results, membranous chambers, mechanisms building, locomotor hyperactivity, larval brain, intralineage adhesion, functional relevance |
| الوصف: | ( A , B ) For all metrics. Control ( wor-GAL4 , tub-Gal80 ts x w 1118 ), n = 35 non-induced adult males and n = 55 induced adult males. shg RNAi ( wor-GAL4 , tub-Gal80 ts x shg RNAi VDRC27082 ), n = 35 non-induced adult males and n = 55 induced adult males. nrx-IV RNAi ( wor-GAL4 , tub-Gal80 ts x nrx-IV RNAI BDSC32424 ), n = 35 non-induced adult males and n = 55 induced adult males. nrg RNAi ( wor-GAL4 , tub-Gal80 ts x nrg RNAI BDSC37496 ), n = 35 non-induced adult males and n = 55 induced adult males. ( A ) Percentage of global time moving during the Dark period (% moving, ratio between total moving time and total time) in non-induced (flies always kept at 18°C before the recordings) and induced (flies shifted to 29°C from early larval stage to early pupal stage) conditions. Data statistics: Kruskal–Wallis H test with Dunn’s multiple comparisons test for both non-induced and induced conditions. p (non-induced) < 0.0001 and p (induced) < 0.0001 for the Kruskal–Wallis H test on grouped dataset. P values from Dunn’s multiple comparisons test are displayed on the graph. Results are presented as box and whisker plots. ( B ) Percentage of global time moving during the Light period (% moving, ratio between total moving time and total time) in non-induced (flies always kept at 18°C before the recordings) and induced (flies shifted to 29°C from early larval stage to early pupal stage) conditions. Data statistics: Kruskal–Wallis H test with Dunn’s multiple comparisons test for both non-induced and induced conditions. p (non-induced) = 0.0588 and p (induced) < 0.0001 for the Kruskal–Wallis H test on grouped dataset. P values from Dunn’s multiple comparisons test are displayed on the graph. Results are presented as box and whisker plots. For all box and whisker plots: whiskers mark the minimum and maximum, the box includes the 25th–75th percentile, and the line in the box is the median. Individual values are superimposed. The data underlying this figure’s quantifications can be found in S1 Data . Nrg, Neuroglian; ... |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/figure/Loss_of_Nrx-IV_and_Nrg_adhesions_in_NSC_lineages_during_development_results_in_locomotor_hyperactivity_in_the_adults_/24537877 |
| DOI: | 10.1371/journal.pbio.3002352.s011 |
| الاتاحة: | https://doi.org/10.1371/journal.pbio.3002352.s011 https://figshare.com/articles/figure/Loss_of_Nrx-IV_and_Nrg_adhesions_in_NSC_lineages_during_development_results_in_locomotor_hyperactivity_in_the_adults_/24537877 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.290604F2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pbio.3002352.s011 |
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