Academic Journal
Complement activation in IgA nephropathy
| العنوان: | Complement activation in IgA nephropathy |
|---|---|
| المؤلفون: | Medjeral-Thomas, NR, Cook, HT, Pickering, MC |
| المساهمون: | Wellcome Trust |
| المصدر: | 12 ; 1 |
| بيانات النشر: | Springer Verlag |
| سنة النشر: | 2021 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Immunology, Pathology, Complement, IgA nephropathy, MANNAN-BINDING LECTIN, H-RELATED PROTEIN-5, GLOMERULAR DEPOSITION, PATHWAY, ECULIZUMAB, C3, SUSCEPTIBILITY, PATHOGENESIS, VARIANTS, INSIGHTS, 1103 Clinical Sciences |
| الوصف: | IgA nephropathy pathogenesis is incompletely understood, and this limits the development of disease-specific biomarkers and effective therapies. Evidence of complement activity in IgA nephropathy is well established. However, a growing body of research indicates complement activity is an important contributor to IgA nephropathy pathology. In particular, multiple associations have been identified between complement alternative, lectin and terminal pathway proteins and IgA nephropathy severity. Recently, we have also gained insight into possible mechanisms that could link glomerular IgA deposition, complement activity, glomerular inflammation and disease severity. Ongoing clinical trials of therapeutic complement inhibitors will provide insight into the importance of complement activity to IgA nephropathy pathogenesis. Further research into mechanisms of complement activity is essential to improving our understanding and management of patients with IgA nephropathy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1863-2297 |
| Relation: | Springer Seminars in Immunopathology; http://hdl.handle.net/10044/1/91317; 212252/Z/18/Z |
| DOI: | 10.1007/s00281-021-00882-9 |
| الاتاحة: | http://hdl.handle.net/10044/1/91317 https://doi.org/10.1007/s00281-021-00882-9 |
| Rights: | © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.290559D9 |
| قاعدة البيانات: | BASE |
| تدمد: | 18632297 |
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| DOI: | 10.1007/s00281-021-00882-9 |