Academic Journal
Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates
| العنوان: | Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates |
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| المؤلفون: | Marques, Mariana, Ramos, Bruno, Albuquerque, Hélio, Pereira, Marisa, Ribeiro, Diana Roberta, Nunes, Alexandre, Sarabando, Jéssica, Brás, Daniela, Ferreira, Ana Rita, Vitorino, Rui, Amorim, Maria João, Silva, Artur M. S., Soares, Ana Raquel, Ribeiro, Daniela |
| سنة النشر: | 2024 |
| المجموعة: | Universidade Católica Portuguesa: Veritati - Repositório Institucional |
| الوصف: | Influenza A virus (IAV) employs multiple strategies to manipulate cellular mechanisms and support proper virion formation and propagation. In this study, we performed a detailed analysis of the interplay between IAV and the host cells’ proteostasis throughout the entire infectious cycle. We reveal that IAV infection activates the inositol requiring enzyme 1 (IRE1) branch of the unfolded protein response, and that this activation is important for an efficient infection. We further observed the accumulation of virus-induced insoluble protein aggregates, containing both viral and host proteins, associated with a dysregulation of the host cell RNA metabolism. Our data indicate that this accumulation is important for IAV propagation and favors the final steps of the infection cycle, more specifically the virion assembly. These findings reveal additional mechanisms by which IAV disrupts host proteostasis and uncovers new cellular targets that can be explored for the development of host-directed antiviral strategies. ; info:eu-repo/semantics/publishedVersion |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2589-0042 |
| Relation: | http://hdl.handle.net/10400.14/44142; 85185568692; PMC10884513; 001200570800001 |
| DOI: | 10.1016/j.isci.2024.109100 |
| الاتاحة: | http://hdl.handle.net/10400.14/44142 https://doi.org/10.1016/j.isci.2024.109100 |
| Rights: | openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.28DAAD6A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 25890042 |
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| DOI: | 10.1016/j.isci.2024.109100 |