التفاصيل البيبلوغرافية
| العنوان: |
Pan-Cancer analysis of the expression and regulation of matrisome genes across 32 tumor types |
| المؤلفون: |
Izzi, V. (Valerio), Lakkala, J. (Juho), Devarajan, R. (Raman), Kääriäinen, A. (Anni), Koivunen, J. (Jarkko), Heljasvaara, R. (Ritva), Pihlajaniemi, T. (Taina) |
| بيانات النشر: |
Elsevier |
| سنة النشر: |
2019 |
| المجموعة: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| مصطلحات موضوعية: |
Gene regulation, Matrisome, Pan-Cancer, Prognostic, Therapy, Tumor |
| الوصف: |
The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines and growth factors collectively referred to as the matrisome. Studies on the cancer matrisome have been performed for single or few neoplasms, but a more systematic analysis is still missing. Here we present a Pan-Cancer study of matrisome gene expression in 10,487 patients across 32 tumor types, supplemented with transcription factors (TFs) and driver genes/pathways regulating each tumor’s matrisome. We report on 919 TF-target pairs, either used specifically or shared across tumor types, and their prognostic significance, 40 master regulators, 31 overarching regulatory pathways and the potential for druggability with FDA-approved cancer drugs. These results provide a comprehensive transcriptional architecture of the cancer matrisome and suggest the need for development of specific matrisome-targeting approaches for future therapies. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| الاتاحة: |
http://urn.fi/urn:nbn:fi-fe2019121146728 |
| Rights: |
info:eu-repo/semantics/openAccess ; © 2019 University Of Oulu. Published by Elsevier B.V. This is an open access article under the CC BY license(http://creativecommons.org/licenses/by/4.0/). ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.28CDEDB5 |
| قاعدة البيانات: |
BASE |