Academic Journal
Efficacy of phage therapy in preclinical models of bacterial infection: a systematic review and meta-analysis.
| العنوان: | Efficacy of phage therapy in preclinical models of bacterial infection: a systematic review and meta-analysis. |
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| المؤلفون: | Gómez-Ochoa, Sergio Alejandro, Pitton, Melissa, Valente, Luca G, Sosa Vesga, Cristian David, Largo, Jorge, Quiroga-Centeno, Andrea Carolina, Hernández Vargas, Juliana Alexandra, Trujillo-Cáceres, Silvia Juliana, Muka, Taulant, Cameron, David R, Que, Yok-Ai |
| المصدر: | Gómez-Ochoa, Sergio Alejandro; Pitton, Melissa; Valente, Luca G; Sosa Vesga, Cristian David; Largo, Jorge; Quiroga-Centeno, Andrea Carolina; Hernández Vargas, Juliana Alexandra; Trujillo-Cáceres, Silvia Juliana; Muka, Taulant; Cameron, David R; Que, Yok-Ai (2022). Efficacy of phage therapy in preclinical models of bacterial infection: a systematic review and meta-analysis. The Lancet Microbe, 3(12), e956-e968. Elsevier 10.1016/S2666-5247(22)00288-9 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2022 |
| المجموعة: | BORIS (Bern Open Repository and Information System, University of Bern) |
| مصطلحات موضوعية: | 610 Medicine & health, 360 Social problems & social services |
| الوصف: | BACKGROUND Antimicrobial resistance of bacterial pathogens is an increasing clinical problem and alternative approaches to antibiotic chemotherapy are needed. One of these approaches is the use of lytic bacterial viruses known as phage therapy. We aimed to assess the efficacy of phage therapy in preclinical animal models of bacterial infection. METHODS In this systematic review and meta-analysis, MEDLINE/Ovid, Embase/Ovid, CINAHL/EbscoHOST, Web of Science/Wiley, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Google Scholar were searched from inception to Sept 30, 2021. Studies assessing phage efficacy in animal models were included. Only studies that assessed the efficacy of phage therapy in treating established bacterial infections in terms of survival and bacterial abundance or density were included. Studies reporting only in-vitro or ex-vivo results and those with incomplete information were excluded. Risk-of-bias assessment was performed using the Systematic Review Centre for Laboratory Animal Experimentation tool. The main endpoints were animal survival and tissue bacterial burden, which were reported using pooled odds ratios (ORs) and mean differences with random-effects models. The I2 measure and its 95% CI were also calculated. This study is registered with PROSPERO, CRD42022311309. FINDINGS Of the 5084 references screened, 124 studies fulfilled the selection criteria. Risk of bias was high for 70 (56%) of the 124 included studies; therefore, only studies classified as having a low-to-moderate risk of bias were considered for quantitative data synthesis (n=32). Phage therapy was associated with significantly improved survival at 24 h in systemic infection models (OR 0·08 [95% CI 0·03 to 0·20]; I2=55% [95% CI 8 to 77]), skin infection (OR 0·08 [0·04 to 0·19]; I2 = 0% [0 to 79]), and pneumonia models (OR 0·13 [0·06 to 0·31]; I2=0% [0 to 68]) when compared with placebo. Animals with skin infections (mean difference -2·66 [95% CI -3·17 to -2·16]; I2 = 95% [90 to ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://boris.unibe.ch/174743/ |
| الاتاحة: | https://boris.unibe.ch/174743/8/G_mez-Ochoa_LancetMicrobe_2022.pdf https://boris.unibe.ch/174743/ |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.28BE5BC0 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |