Academic Journal
Combined exercise training decreases blood pressure in OLDER women with NOS3 polymorphism providing changes in differentially methylated regions (DMRs)
| العنوان: | Combined exercise training decreases blood pressure in OLDER women with NOS3 polymorphism providing changes in differentially methylated regions (DMRs) |
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| المؤلفون: | da Silva Rodrigues, Guilherme, Yumi Noronha, Natalia, Ribeiro de Lima, João Gabriel, Harumi Yonehara Noma, Isabela, Crystine da Silva Sobrinho, Andressa, Maria Diani, Luísa, Pinto, Ana P., Pereira Rodrigues, Karine, Augusta de Souza Pinhel, Marcela, Barbosa Nonino, Carla, Moriguchi Watanabe, Lígia, Roberto Bueno Júnior, Carlos |
| المصدر: | da Silva Rodrigues , G , Yumi Noronha , N , Ribeiro de Lima , J G , Harumi Yonehara Noma , I , Crystine da Silva Sobrinho , A , Maria Diani , L , Pinto , A P , Pereira Rodrigues , K , Augusta de Souza Pinhel , M , Barbosa Nonino , C , Moriguchi Watanabe , L & Roberto Bueno Júnior , C 2024 , ' Combined exercise training decreases blood pressure in OLDER women with NOS3 polymorphism providing changes in differentially methylated regions (DMRs) ' , Epigenetics , vol. 19 , no. 1 .... |
| سنة النشر: | 2024 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | DNA methylation, epigenetics, Physical exercise, women |
| الوصف: | The mechanisms by which the ageing process is associated to an unhealthy lifestyle and how they play an essential role in the aetiology of systemic arterial hypertension have not yet been completely elucidated. Our objective is to investigate the influence of NOS3 polymorphisms [−786T > C and (Glu298Asp)] on systolic blood pressure (SBP) and diastolic blood pressure (DBP) response, differentially methylated regions (DMRs), and physical fitness of adult and older women after a 14-week combined training intervention. The combined training was carried out for 14 weeks, performed 3 times a week, totalling 180 minutes weekly. The genotyping experiment used Illumina Infinium Global Screening Array version 2.0 (GSA V2.0) and Illumina’s EPIC Infinium Methylation BeadChip. The participants were separated into SNP rs2070744 in TT (59.7 ± 6.2 years) and TC + CC (60.0 ± 5.2 years), and SNP rs17999 in GluGlu (58.8 ± 5.7 years) and GluAsp + AspAsp (61.6 ± 4.9 years). We observed an effect of time for variables BP, physical capacities, and cholesterol. DMRs related to SBP and DBP were identified for the rs2070744 and rs17999 groups pre- and decreased numbers of DMRs post-training. When we analysed the effect of exercise training in pre- and post-comparisons, the GluGlu SNP (rs17999) showed 10 DMRs, and after enrichment, we identified several biological biases. The combined training improved the SBP and DBP values of the participants regardless of the SNPs. In addition, exercise training affected DNA methylation differently between the groups of NOS3 polymorphisms. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1080/15592294.2024.2375030 |
| الاتاحة: | https://hdl.handle.net/11370/b7974c45-9744-4041-b9ec-311c62cb0a7a https://research.rug.nl/en/publications/b7974c45-9744-4041-b9ec-311c62cb0a7a https://doi.org/10.1080/15592294.2024.2375030 https://pure.rug.nl/ws/files/1119231794/Combined_exercise_training_decreases_blood_pressure_in_OLDER_women_with_NOS3_polymorphism_providing_changes_in_differentially_methylated_regions_DMRs.pdf http://www.scopus.com/inward/record.url?scp=85197711443&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.287E73C3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/15592294.2024.2375030 |
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