Academic Journal
FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer
| العنوان: | FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer |
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| المؤلفون: | Mangé, Alain, Coyaud, Etienne, Desmetz, Caroline, Laurent, Estelle, Béganton, Benoit, Coopman, Peter, Raught, Brian, Solassol, Jérôme |
| المساهمون: | Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Ontario Institute for Cancer Research Canada (OICR), Ontario Institute for Cancer Research, Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Biocommunication en Cardio-Métabolique (BC2M), Université de Montpellier (UM), Service de Biopathologie CHRU Montpellier, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier) |
| المصدر: | ISSN: 1838-7640 ; Theranostics ; https://hal.umontpellier.fr/hal-02359160 ; Theranostics, 2019, 9 (23), pp.7003-7015. ⟨10.7150/thno.35561⟩. |
| بيانات النشر: | HAL CCSD Ivyspring International Publisher |
| سنة النشر: | 2019 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | FKBP52, FKBP4, BioID, AKT, breast cancer, mTOR, [SDV.CAN]Life Sciences [q-bio]/Cancer |
| الوصف: | International audience ; Purpose: Among the FKBP family members, FKBP4 has been described to have a potential role in tumorigenesis, and as a putative tissue marker. We previously showed that FKBP4, an HSP90-associated co-chaperone, can elicit immune response as a tumor-specific antigen, and are overexpressed in breast cancer. Experimental design: In this study, we examined how loss of FKBP4 affect breast cancer progression and exploited protein interactomics to gain mechanistic insight into this process. Results: We found that FKBP4 expression is associated with breast cancer progression and prognosis, especially of ER-negative breast cancer. Furthermore, FKBP4 depletion specifically reduces cell growth and proliferation of triple negative breast cancer cell model and xenograft tumor model. Using specific protein interactome strategy by BirA proximity-dependent biotin identification, we demonstrated that FKBP4 is a novel PI3K-Akt-mTOR proximal interacting protein. Conclusion: Our results suggest that FKBP4 interacts with PI3K and can enhance Akt activation through PDK1 and mTORC2. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.7150/thno.35561 |
| الاتاحة: | https://hal.umontpellier.fr/hal-02359160 https://hal.umontpellier.fr/hal-02359160v1/document https://hal.umontpellier.fr/hal-02359160v1/file/Theranostics_v09p7003.pdf https://doi.org/10.7150/thno.35561 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.286F7BD1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7150/thno.35561 |
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