Academic Journal
Abnormal retinal capillary blood flow in autosomal dominant Alzheimer's disease
| العنوان: | Abnormal retinal capillary blood flow in autosomal dominant Alzheimer's disease |
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| المؤلفون: | Singer, Maxwell B., Ringman, John M., Chu, Zhongdi, Zhou, Xiao, Jiang, Xuejuan, Shahidzadeh, Anoush, Wang, Ruikang K., Kashani, Amir H. |
| المساهمون: | National Institutes of Health |
| المصدر: | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring ; volume 13, issue 1 ; ISSN 2352-8729 2352-8729 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2021 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Introduction This study characterizes retinal capillary blood flow in subjects with autosomal dominant Alzheimer's disease (ADAD)‐causing mutations. Methods Carriers of PSEN1 or APP mutations were prospectively recruited and split into early‐stage (ES) and late‐stage (LS) groups. Controls were normal subjects and non‐carriers from the at‐risk group. Capillary blood flow was quantified using an optical coherence tomography angiography‐based measure of erythrocyte flux through capillary segments. Statistical analyses were adjusted for correlation between two eyes of the same subject. Results ES carriers had significantly greater capillary blood flow than controls and LS carriers. ES and LS carriers had significantly greater capillary blood flow heterogeneity than controls. There was no difference between capillary blood flow of LS carriers and controls. Discussion ES ADAD carriers demonstrate increased retinal capillary blood flow and flow heterogeneity compared to controls. These findings support the hypothesis that increased perfusion is a pathophysiologic feature of presymptomatic stages of ADAD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/dad2.12162 |
| الاتاحة: | http://dx.doi.org/10.1002/dad2.12162 https://onlinelibrary.wiley.com/doi/pdf/10.1002/dad2.12162 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/dad2.12162 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.285D7E50 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/dad2.12162 |
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