Academic Journal
Mesenchymal stem cells derived from different origins have unique sensitivities to different chemotherapeutic agents
| العنوان: | Mesenchymal stem cells derived from different origins have unique sensitivities to different chemotherapeutic agents |
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| المؤلفون: | Qi, Zhengyu, Zhang, Yanmin, Liu, Lin, Guo, Xin, Qin, Jie, Cui, Guanghui |
| المساهمون: | Cui, GH (reprint author), Peking Univ, Shenzhen Hosp, Med Ctr, Guangdong Key Lab Male Reprod Med & Genet, Guangzhou 518036, Guangdong, Peoples R China., Peking Univ, Shenzhen Hosp, Med Ctr, Guangdong Key Lab Male Reprod Med & Genet, Guangzhou 518036, Guangdong, Peoples R China., Hong Kong Univ Sci & Technol, Guangzhou 518036, Guangdong, Peoples R China., Peoples Hosp Donghai, Donghai 222300, Jiangsu, Peoples R China. |
| المصدر: | SCI ; PubMed |
| بيانات النشر: | cell biology international |
| سنة النشر: | 2012 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | adipose-tissue-derived mesenchymal stem cell, apoptosis, bone-marrow-derived mesenchymal stem cell, chemosensitivity, proliferation, senescence, HUMAN ADIPOSE-TISSUE, BONE-MARROW, BUSULFAN, PROTEIN, KINASE |
| الوصف: | BMSCs (bone-marrow-derived mesenchymal stem cells) and ADSCs (adipose tissue-derived mesenchymal stem cells) are virtually identical in cell surface marker profile and differentiation potential. These cell populations have promising characteristics for clinical application. We have investigated the sensitivity of these cell populations to various chemotherapeutic agents by testing the inhibition of cell proliferation, low molecular DNA bands formation, in situ apoptosis, apoptosis-related gene expression and cell senescence after treatment. BU (busulfan), methotrexate and doxorubicin treatment led to a marked and dose-dependent reduction in cell viability compared with 5-FU (5-fluorouracil) treatment. Different expression patterns of apoptosis-related genes were found in the BMSCs and ADSCs following treatment with the agents, but no low molecular mass DNA bands were detected. BMSCs had a higher percentage of apoptotic and senescent cells following treatment with chemotherapeutic agents compared with ADSCs. These findings suggest that these two cell populations respond differently to chemotherapy treatment. ADSCs are more resistant than BMSCs to chemotherapy-induced senescence and apoptosis, indicating that they might be more advantageous to use in the clinic than BMSCs. ; Cell Biology ; SCI(E) ; PubMed ; 3 ; ARTICLE ; 9 ; 857-862 ; 36 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1065-6995 |
| Relation: | CELL BIOLOGY INTERNATIONAL.2012,36,(9),857-862.; 660273; http://hdl.handle.net/20.500.11897/192120; WOS:000308286000011 |
| DOI: | 10.1042/CBI20110637 |
| الاتاحة: | https://hdl.handle.net/20.500.11897/192120 https://doi.org/10.1042/CBI20110637 |
| رقم الانضمام: | edsbas.28517317 |
| قاعدة البيانات: | BASE |
| تدمد: | 10656995 |
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| DOI: | 10.1042/CBI20110637 |