Academic Journal
Gut permeability and its clinical relevance in schizophrenia
| العنوان: | Gut permeability and its clinical relevance in schizophrenia |
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| المؤلفون: | Ishida, Ikki, Ogura, Jun, Aizawa, Emiko, Ota, Miho, Hidese, Shinsuke, Yomogida, Yukihito, Matsuo, Junko, Yoshida, Sumiko, Kunugi, Hiroshi |
| المساهمون: | Japan Agency for Medical Research and Development |
| المصدر: | Neuropsychopharmacology Reports ; volume 42, issue 1, page 70-76 ; ISSN 2574-173X 2574-173X |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Aim We aimed to examine the gut permeability in patients with schizophrenia and its relevance to schizophrenia symptoms, medication, cognitive functions, and blood immune markers. Methods We selected 22 patients with schizophrenia (mean age: 37.9 ± 10.5 years) comprising 9 men and 13 women. Furthermore, we included 86 healthy controls (mean age: 43.5 ± 11.0 years) comprising 41 men and 45 women. All participants were biologically unrelated and of Japanese descent. We used the Positive and Negative Syndrome Scale (PANSS) and Brief Assessment of Cognition in Schizophrenia (BACS) to measure the severity of schizophrenia symptoms and cognitive functions, respectively. The lactulose‐mannitol loading test was used to measure the permeability of the small intestine. Furthermore, we used the lactulose to mannitol ratio (LMR) as an index of gut permeability. We measured the C‐reactive protein and natural killer (NK) cell activity in the blood as highly sensitive immune markers. Results The patients had a significantly higher rate of “leaky gut” (defined as LMR ≥ 0.1) compared to the control group (22.7% vs. 5.8%, odds ratio: 4.8 [95% confidence interval, 1.2‐18.3], Fisher's exact test, P = 0.03). There was no significant correlation between the LMR and PANSS scores or in the daily antipsychotic dose. In addition, the LMR was negatively correlated with the total Z ‐score of the BACS and NK cell activity in the patients. Conclusions Our results suggest a higher rate of abnormally increased gut permeability in patients with schizophrenia than in controls. Moreover, gut permeability may be related to the cognitive and cellular immunity function of patients with schizophrenia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/npr2.12227 |
| الاتاحة: | http://dx.doi.org/10.1002/npr2.12227 https://onlinelibrary.wiley.com/doi/pdf/10.1002/npr2.12227 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/npr2.12227 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.28500FD5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/npr2.12227 |
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