التفاصيل البيبلوغرافية
| العنوان: |
Oxidative Stress, Induced by Sub-Lethal Doses of BDE 209, Promotes Energy Management and Cell Cycle Modulation in the Marine Fish Cell Line SAF-1 |
| المؤلفون: |
Cristobal Espinosa Ruiz, Simona Manuguerra, Alberto Cuesta, Andrea Santulli, Concetta M. Messina |
| المصدر: |
International Journal of Environmental Research and Public Health; Volume 16; Issue 3; Pages: 474 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2019 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
PBDE-209, Sparus aurata fibroblast, oxidative stress, biomarkers |
| جغرافية الموضوع: |
agris |
| الوصف: |
The effects of sub-lethal doses of polybrominated diphenyl ether (PBDE)-209 in terms of toxicity, oxidative stress, and biomarkers were evaluated in the Sparus aurata fibroblast cell line (SAF-1). Vitality and oxidative stress status were studied after incubation with PBDE for 72 h. Concomitantly, the quantification of proteins related to cell cycle and DNA repair (p53), cell proliferation (extracellular signal–regulated kinase 1 (ERK1)), energetic restriction (hypoxia-inducible factor 1 (HIF1)), and redox status (Nuclear factor erythroid 2–related factor 2 (NRF2)) was also determined after prolonged exposure (7–15 days) by immunoblotting. Our results demonstrated that rising concentrations of PBDEs exposure-induced oxidative stress, and that this event modulates different cell pathways related to cell cycle, cell signaling, and energetic balance in the long term, indicating the negative impact of sub-lethal dose exposure to cell homeostasis. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://dx.doi.org/10.3390/ijerph16030474 |
| DOI: |
10.3390/ijerph16030474 |
| الاتاحة: |
https://doi.org/10.3390/ijerph16030474 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.2842439A |
| قاعدة البيانات: |
BASE |