Academic Journal
Qualitative mucin disorders in patients with primary Sjögren's syndrome: a literature review
| العنوان: | Qualitative mucin disorders in patients with primary Sjögren's syndrome: a literature review |
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| المؤلفون: | Massimo Fusconi, Francesca Candelori, Lior Weiss, Annachiara Riccio, Roberta Priori, Rita Businaro, Linda Mastromanno, Isotta Musy, Marco de Vincentiis, Antonio Greco |
| المساهمون: | Fusconi, Massimo, Candelori, Francesca, Weiss, Lior, Riccio, Annachiara, Priori, Roberta, Businaro, Rita, Mastromanno, Linda, Musy, Isotta, DE VINCENTIIS, Marco, Greco, Antonio |
| بيانات النشر: | Medicina Oral SL, [2004] Valencia, Spagna |
| سنة النشر: | 2021 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | primary Sjögren's syndrome, mucin, MUC7, MUC5B, MUC1, sulphate oligosaccharides |
| الوصف: | Background: It is a common opinion that Primary Sjögren Syndrome (pSS) damages the exocrine glands and determines the reduction of secreted saliva, some studies show that there are qualitative anomalies of the mucins produced in saliva, including MUC7, MUC5B, MUC1. The purpose of this study is to trace all the information useful to establish whether there is a qualitative or quantitative defect of the mucins in the pSS. Material and Methods: We reviewed the literature by looking for publications relevant to the topic in electronic databases. Sixteen articles met the search criteria. The studies were divided into two categories, those that studied the rheological characteristics of the saliva and those that studied the structural and / or metabolism modifications of the muciparous cells in the salivary glands. Results: in Patients with pSS, xerostomia and the reduction of salivary spinnbarkeit are only partially related to the reduction of the unstimulated salivary flow. In pSS, pathological alterations of mucins’ chemical-physical properties prevail as a cause of the clinical characteristics. Moreover, in pSS there are structural and metabolism changes in salivary glands’ muciparous cells. Conclusions: There is much evidence that supports the presence of qualitative alterations in the saliva’s rheological properties in Patients with pSS, and these are the main cause, more than the reduction of the unstimulated salivary flow, of the disease clinical characteristics - dry mouth and complications in the oral cavity. Therefore we propose to add to the classification criteria of pSS also a qualitative test of salivary glycoproteins. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/33247578; info:eu-repo/semantics/altIdentifier/wos/WOS:000604964100009; volume:26; issue:1; firstpage:71; lastpage:77; numberofpages:7; journal:MEDICINA ORAL, PATOLOGÍA ORAL Y CIRUGÍA BUCAL; http://hdl.handle.net/11573/1471309; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85099052088 |
| DOI: | 10.4317/medoral.23996 |
| الاتاحة: | http://hdl.handle.net/11573/1471309 https://doi.org/10.4317/medoral.23996 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.281B3CBE |
| قاعدة البيانات: | BASE |
| DOI: | 10.4317/medoral.23996 |
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