Academic Journal
Periostin predicts all-cause mortality in male but not female end-stage renal disease patients on hemodialysis
| العنوان: | Periostin predicts all-cause mortality in male but not female end-stage renal disease patients on hemodialysis |
|---|---|
| المؤلفون: | Li, Xitong, Liu, Yvonne, Hocher, Johann-Georg, Chu, Chang, Reichetzeder, Christoph, Kalk, Philipp, Szakallova, Angelika, Chen, Xin, Krämer, Bernhard K., Tepel, Martin, Hocher, Berthold |
| المصدر: | Cardiorenal Medicine ; ISSN 1664-3828 1664-5502 |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 2024 |
| الوصف: | Background: Periostin is a matricellular protein. Elevated serum concentrations of periostin have been reported in patients with various cardiovascular diseases, including heart failure. Patients with end-stage renal disease have a substantially increased risk for cardiovascular diseases. However, there is a lack of clinical studies to clarify the prognostic significance of systemic periostin on all-cause mortality in patients with end-stage renal disease on hemodialysis. Methods: 313 stable end-stage renal disease patients were recruited and followed for five years concerning all-cause mortality. At baseline, we collected blood samples and clinical data. Serum periostin concentrations were measured using a certified ELISA. Results: The optimal cut-off value for serum periostin regarding all-cause mortality, calculated through ROC analysis, was 777.5 pmol/l. Kaplan-Meier survival analysis using this cut-off value demonstrated that higher periostin concentrations are linked to higher all-cause mortality (log-rank test: P = 0.002). Subgroup analysis revealed that serum periostin concentrations only affected all-cause mortality in male but not in female patients (P = 0.002 in male patients and P = 0.474 in female patients). Multivariate Cox regression analyses, adjusted for confounding factors, likewise showed that elevated serum periostin concentrations were positively associated with all-cause mortality in male (P = 0.028) but not in female patients on hemodialysis (P = 0.313). Conclusion: Baseline serum periostin is an independent risk factor for all-cause mortality in male patients with chronic renal disease on hemodialysis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000539765 |
| DOI: | 10.1159/000539765/4254357/000539765.pdf |
| الاتاحة: | http://dx.doi.org/10.1159/000539765 https://karger.com/crm/article-pdf/doi/10.1159/000539765/4254357/000539765.pdf |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ ; https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.28159808 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000539765 |
|---|