Academic Journal
Association of Adiponectin Gene Polymorphism (+T45G) With Acute Coronary Syndrome and Circulating Adiponectin Levels
| العنوان: | Association of Adiponectin Gene Polymorphism (+T45G) With Acute Coronary Syndrome and Circulating Adiponectin Levels |
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| المؤلفون: | Rizk, Nasser M., El-Menyar, Ayman, Marei, Isra, Sameer, Maha, Musad, Tasneem, Younis, Dima, Farag, Fathi, Basem, Nora, Al-Ali, Khalid, Suwaidi, Jassim Al |
| المصدر: | Angiology ; volume 64, issue 4, page 257-265 ; ISSN 0003-3197 1940-1574 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2012 |
| الوصف: | We investigated the association of adiponectin gene polymorphisms (+T45G and +G276T) and adiponectin levels with acute coronary syndrome (ACS) among Arabs in Qatar. A case–control study was performed in 142 Arab patients with ACS and 122 controls. Genotypes were determined using TaqMan real-time polymerase chain reaction assay. The TT, TG, and GG genotype frequencies of the T45G variant were significantly different among cases and controls ( P = .023) but not significant for G276T genotypic frequencies. It was found that only the +45G allele was significantly associated with 3-fold increased risk of ACS (odds ratio = 2.77; 1.03-6.96; P = .043) among patients, using the genetic recessive model. Carriers of GG alleles had significantly lower adiponectin levels compared to TT/TG carriers of T45G in patients with ACS. The present study suggests that only T45G single-nucleotide polymorphism in the adiponectin gene is associated with higher odds for ACS events and has an effect on serum adiponectin levels among Arab populations. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/0003319712455497 |
| الاتاحة: | https://doi.org/10.1177/0003319712455497 https://journals.sagepub.com/doi/pdf/10.1177/0003319712455497 https://journals.sagepub.com/doi/full-xml/10.1177/0003319712455497 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.280B0D7A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/0003319712455497 |
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