التفاصيل البيبلوغرافية
| العنوان: |
Cell size is a determinant of stem cell potential during aging |
| المؤلفون: |
Lengefeld, Jette, Cheng, Chia-Wei, Maretich, Pema, Blair, Marguerite, Hagen, Hannah, McReynolds, Melanie R., Sullivan, Emily, Majors, Kyra, Roberts, Christina, Kang, Joon Ho, Steiner, Joachim D., Miettinen, Teemu P., Manalis, Scott R., Antebi, Adam, Morrison, Sean J., Lees, Jacqueline A., Boyer, Laurie A., Yilmaz, Ömer H., Amon, Angelika |
| المساهمون: |
Institute of Biotechnology, Blood stem cells during health and disease research group |
| بيانات النشر: |
American Association for the Advancement of Science (AAAS) |
| سنة النشر: |
2021 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
HEMATOPOIETIC STEM, SELF-RENEWAL, GENE-EXPRESSION, FUNCTIONAL DECLINE, PROGENITOR CELLS, GROWTH, SENESCENCE, CYCLE, HOMEOSTASIS, MTOR, Biochemistry, cell and molecular biology |
| الوصف: |
Stem cells are remarkably small. Whether small size is important for stem cell function is unknown. We find that hematopoietic stem cells (HSCs) enlarge under conditions known to decrease stem cell function. This decreased fitness of large HSCs is due to reduced proliferation and was accompanied by altered metabolism. Preventing HSC enlargement or reducing large HSCs in size averts the loss of stem cell potential under conditions causing stem cell exhaustion. Last, we show that murine and human HSCs enlarge during aging. Preventing this age-dependent enlargement improves HSC function. We conclude that small cell size is important for stem cell function in vivo and propose that stem cell enlargement contributes to their functional decline during aging. ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
J.L. was supported by the Howard Hughes Medical Institute (HHMI), Jane Coffin Childs Memorial Fund, Swiss National Science Foundation (SNSF), and the Academy of Finland. T.P.M. was supported by the Wellcome Trust (110275/Z/15/Z). This work was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD085866), NCI Cancer Centre core grant P30-CA14051 to the Ostrom Bioinformatics and Computing Core Facility of the Swanson Biotechnology Center, and the MIT Stem Cell Initiative through Fondation MIT. A.An. is also an investigator of the HHMI and the Glenn Foundation for Medical Research. P.M. and L.A.B. were supported by the Mathers Foundation, NIEHS P30-ES002109, and the G. Harold & Leila Y. Mathers Foundation. M.R. M. is supported by the Burroughs Wellcome Fund and HHMI via the PDEP and Hanna H. Gray Fellows Program. J.D.S. and A.An. were supported by ERC Advanced Grant: Nuage and the Max-Planck-Gesellschaft. M.R.M. was supported by the Gray Foundation. C.-W.C. was supported by NIH/R00 (DK123407).; Lengefeld , J , Cheng , C-W , Maretich , P , Blair , M , Hagen , H , McReynolds , M R , Sullivan , E , Majors , K , Roberts , C , Kang , J H , Steiner , J D , Miettinen , T P , Manalis , S R , Antebi , A , Morrison , S J , Lees , J A , Boyer , L A , Yilmaz , Ö H & Amon , A 2021 , ' Cell size is a determinant of stem cell potential during aging ' , Science Advances , vol. 7 , no. 46 , 0271 . https://doi.org/10.1126/sciadv.abk0271; http://hdl.handle.net/10138/337914; 5d0006a3-01f2-4467-b22a-cce63554c4e3; 000720344200015 |
| الاتاحة: |
http://hdl.handle.net/10138/337914 |
| Rights: |
cc_by_nc ; info:eu-repo/semantics/openAccess ; openAccess |
| رقم الانضمام: |
edsbas.27AC53BD |
| قاعدة البيانات: |
BASE |