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Current Prophylaxis and Treatment Approaches for Acute Graft-Versus-Host Disease in Haematopoietic Stem Cell Transplantation for Children With Acute Lymphoblastic Leukaemia

التفاصيل البيبلوغرافية
العنوان: Current Prophylaxis and Treatment Approaches for Acute Graft-Versus-Host Disease in Haematopoietic Stem Cell Transplantation for Children With Acute Lymphoblastic Leukaemia
المؤلفون: Wölf, Matthias, Qayed, Muna, Sykora, Tomas, Bonig, Halvard, Lawitschka, Anita, Díaz de Heredia Rubio, Maria Cristina, Benitez Carabante, Maria Isabel
المساهمون: Institut Català de la Salut, Wölfl M Pediatric Hematology, Oncology and Stem Cell Transplantation, Children's Hospital, Würzburg University Hospital, Würzburg, Germany. Qayed M Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, United States. Benitez Carabante MI, Diaz-de-Heredia C Servei d’Oncologia i Hematologia Pediàtriques, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Sykora T Haematopoietic Stem Cell Transplantation Unit, Department of Pediatric Haematology and Oncology, Comenius University Children's Hospital, Bratislava, Slovakia. Bonig H Institute for Transfusion Medicine and Immunohematology, Goethe-University Frankfurt/Main, Frankfurt, Germany. German Red Cross Blood Service BaWüHe, Frankfurt, Germany. Lawitschka A Department of Pediatrics, St. Anna Kinderspital and Children's Cancer Research Institute, Medical University of Vienna, Vienna, Austria, Vall d'Hebron Barcelona Hospital Campus
المصدر: Scientia
بيانات النشر: Frontiers Media
سنة النشر: 2022
مصطلحات موضوعية: Empelt contra l'hoste, Malaltia de l', Cèl·lules mare hematopoètiques - Trasplantació, Leucèmia limfoblàstica, DISEASES::Neoplasms::Neoplasms by Histologic Type::Leukemia, ENFERMEDADES::neoplasias::neoplasias por tipo histológico::leucemia
الوصف: Acute lymphoblastic leukaemia; Children ; Leucemia linfoblástica aguda; Niños ; Leucèmia limfoblàstica aguda; Nens ; Acute graft-versus-host disease (aGvHD) continues to be a leading cause of morbidity and mortality following allogeneic haematopoietic stem cell transplantation (HSCT). However, higher event-free survival (EFS) was observed in patients with acute lymphoblastic leukaemia (ALL) and grade II aGvHD vs. patients with no or grade I GvHD in the randomised, controlled, open-label, international, multicentre Phase III For Omitting Radiation Under Majority age (FORUM) trial. This finding suggests that moderate-severity aGvHD is associated with a graft-versus-leukaemia effect which protects against leukaemia recurrence. In order to optimise the benefits of HSCT for leukaemia patients, reduction of non-relapse mortality—which is predominantly caused by severe GvHD—is of utmost importance. Herein, we review contemporary prophylaxis and treatment options for aGvHD in children with ALL and the key challenges of aGvHD management, focusing on maintaining the graft-versus-leukaemia effect without increasing the severity of GvHD. ; This study received funding from the St. Anna Children's Cancer Research Institute, Vienna, Austria.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
تدمد: 2296-2360
35071133
Relation: Frontiers in Pediatrics;9; https://doi.org/10.3389/fped.2021.784377; Wölfl M, Qayed M, Benitez Carabante MI, Sykora T, Bonig H, Lawitschka A, et al. Current Prophylaxis and Treatment Approaches for Acute Graft-Versus-Host Disease in Haematopoietic Stem Cell Transplantation for Children With Acute Lymphoblastic Leukaemia. Front Pediatr. 2022 Jan;9:784377.; https://hdl.handle.net/11351/7826; 000745907700001
DOI: 10.3389/fped.2021.784377
الاتاحة: https://hdl.handle.net/11351/7826
https://doi.org/10.3389/fped.2021.784377
Rights: Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.279D15DA
قاعدة البيانات: BASE
الوصف
تدمد:22962360
35071133
DOI:10.3389/fped.2021.784377