التفاصيل البيبلوغرافية
| العنوان: |
Exploring the cardioprotective properties of lantana camara aqueous extract in the context of psoriatic pathophysiology lesion in mice |
| المؤلفون: |
Rusul k., hashim, Orooba Mohammed, Saeed Ibrahim |
| المصدر: |
Revista Latinoamericana de Hipertension, 18(10), (2023-12-30) |
| بيانات النشر: |
Zenodo |
| سنة النشر: |
2023 |
| المجموعة: |
Zenodo |
| مصطلحات موضوعية: |
Cardiac Pathophysiology, Lantana Camara Extract, Anti-Inflammatory, Imiquimod-Induced, Interleukin Levels |
| الوصف: |
The aim of this research was to assess the anti-inflammatory properties of Lantana camara extracts in the context of cardiac pathophysiology. The study involved the extraction of dried leaves from both Lantana camara and another plant through a maceration process. To induce a cardiac condition, the subjects (mice) were treated topically with a 5% imiquimod solution for a period of 10 days. Subsequently, they were treated with L. camara extract and a retinoid for another 10 days. The 50 mice were divided into five groups as follows: Group A served as a control with no induction and no treatment, Group B was induced to develop a cardiac condition without receiving any treatment, Group C was induced to develop a cardiac condition and treated topically with 0.05% L. camara extract, and Group D was induced to develop a cardiac condition and treated topically with 0.025% retinoid. The parameters under evaluation included clinical symptoms, gross examination, the severity of the cardiac affected area, interleukin-6 and interleukin-17 levels, and histopathological examination of cardiac tissues. Clinical symptoms, such as behavior, physical activity, and feeding habits, returned to normal in the treated groups. Furthermore, the gross examination revealed a gradual reduction in cardiac symptoms, such as scars, inflammation, and discoloration. Notably, the L. camara extract exhibited a stronger anti-inflammatory effect on the cardiac tissues of the mice with induced cardiac conditions as compared to the retinoid treatment. The levels of interleukin-6 and interleukin-17 in the serum were significantly reduced by all treatments (P≤0.05), with the L. camara extract showing a more pronounced effect. In conclusion, the findings of this study suggest that Lantana camara extract possesses significant anti-inflammatory and anti-cardiac pathophysiological properties in a mouse model with imiquimod-induced cardiac conditions. These results point to the potential therapeutic use of L. camara extract for the treatment of cardiac ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
https://doi.org/10.5281/zenodo.10443650; https://doi.org/10.5281/zenodo.10443651; oai:zenodo.org:10443651 |
| DOI: |
10.5281/zenodo.10443651 |
| الاتاحة: |
https://doi.org/10.5281/zenodo.10443651 |
| Rights: |
info:eu-repo/semantics/openAccess ; Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcode |
| رقم الانضمام: |
edsbas.27857C0D |
| قاعدة البيانات: |
BASE |