التفاصيل البيبلوغرافية
| العنوان: |
Diabetes, Obesity, and Inflammation: Impact on Clinical and Radiographic Features of Breast Cancer |
| المؤلفون: |
Braden Miller, Hunter Chalfant, Alexandra Thomas, Elizabeth Wellberg, Christina Henson, Molly W. McNally, William E. Grizzle, Ajay Jain, Lacey R. McNally |
| المصدر: |
International Journal of Molecular Sciences; Volume 22; Issue 5; Pages: 2757 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
diabetes, obesity, imaging, molecular imaging, breast cancer |
| جغرافية الموضوع: |
agris |
| الوصف: |
Obesity, diabetes, and inflammation increase the risk of breast cancer, the most common malignancy in women. One of the mainstays of breast cancer treatment and improving outcomes is early detection through imaging-based screening. There may be a role for individualized imaging strategies for patients with certain co-morbidities. Herein, we review the literature regarding the accuracy of conventional imaging modalities in obese and diabetic women, the potential role of anti-inflammatory agents to improve detection, and the novel molecular imaging techniques that may have a role for breast cancer screening in these patients. We demonstrate that with conventional imaging modalities, increased sensitivity often comes with a loss of specificity, resulting in unnecessary biopsies and overtreatment. Obese women have body size limitations that impair image quality, and diabetes increases the risk for dense breast tis-sue. Increased density is known to obscure the diagnosis of cancer on routine screening mammography. Novel molecu-lar imaging agents with targets such as estrogen receptor, human epidermal growth factor receptor 2 (HER2), pyrimi-dine analogues, and ligand-targeted receptor probes, among others, have potential to reduce false positive results. They can also improve detection rates with increased resolution and inform therapeutic decision making. These emerg-ing imaging techniques promise to improve breast cancer diagnosis in obese patients with diabetes who have dense breasts, but more work is needed to validate their clinical application. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms22052757 |
| DOI: |
10.3390/ijms22052757 |
| الاتاحة: |
https://doi.org/10.3390/ijms22052757 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.26F527EE |
| قاعدة البيانات: |
BASE |