Academic Journal
Chronic Toxoplasma gondii infection and sleep‐wake alterations in mice
| العنوان: | Chronic Toxoplasma gondii infection and sleep‐wake alterations in mice |
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| المؤلفون: | Dupont, Damien, Lin, Jian‐Sheng, Peyron, François, Akaoka, Hideo, Wallon, Martine |
| المصدر: | CNS Neuroscience & Therapeutics ; volume 27, issue 8, page 895-907 ; ISSN 1755-5930 1755-5949 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2021 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Aim Toxoplasma gondii ( Tg ) is an intracellular parasite infecting more than a third of the human population. Yet, the impact of Tg infection on sleep, a highly sensitive index of brain functions, remains unknown. We designed an experimental mouse model of chronic Tg infection to assess the effects on sleep‐wake states. Methods Mice were infected using cysts of the type II Prugniaud strain. We performed chronic sleep‐wake recordings and monitoring as well as EEG power spectral density analysis in order to assess the quantitative and qualitative changes of sleep‐wake states. Pharmacological approach was combined to evaluate the direct impact of the infection and inflammation caused by Tg . Results Infected mouse exhibited chronic sleep‐wake alterations over months, characterized by a marked increase (>20%) in time spent awake and in cortical EEG θ power density of all sleep‐wake states. Meanwhile, slow‐wave sleep decreased significantly. These effects were alleviated by an anti‐inflammatory treatment using corticosteroid dexamethasone. Conclusion We demonstrated for the first time the direct consequences of Tg infection on sleep‐wake states. The persistently increased wakefulness and reduced sleep fit with the parasite's strategy to enhance dissemination through host predation and are of significance in understanding the neurodegenerative and neuropsychiatric disorders reported in infected patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/cns.13650 |
| الاتاحة: | http://dx.doi.org/10.1111/cns.13650 https://onlinelibrary.wiley.com/doi/pdf/10.1111/cns.13650 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cns.13650 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.26EE5237 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/cns.13650 |
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