Academic Journal
Impact of 68Ga-DOTATOC PET/CT in comparison to 111In-Octreotide SPECT/CT in management of neuro-endocrine tumors ; A case report
| العنوان: | Impact of 68Ga-DOTATOC PET/CT in comparison to 111In-Octreotide SPECT/CT in management of neuro-endocrine tumors ; A case report |
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| المؤلفون: | Tolomeo, Anna, Lopopolo, Gaetano, Dimiccoli, Vincenzo, Perioli, Luana, Modoni, Sergio, Scilimati, Antonio |
| المصدر: | Medicine ; volume 99, issue 7, page e19162 ; ISSN 0025-7974 1536-5964 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: | 2020 |
| الوصف: | Rationale: In the diagnostics of neuroendocrine tumors (NETs), scintigraphy and Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) with 111 Indium-Octreotide occupy a prominent place. The introduction in clinical practice of 68 Gallium-labelled somatostatin analogues (DOTA-TOC, DOTA-TATE, DOTA-NOC) for Positron Emission Tomography/Computed Tomography (PET/CT), significantly improved NETs diagnostics due to greater sensitivity and improved lesion detection in addition to better patient convenience and decreased radiation dose. Patient concerns: We report a case of a patient who was diagnosed with a neuroendocrine tumor of the ileocecal valve. Diagnoses: Diagnosis was made by ultrasonography, CT, and colonoscopy. Hystology after surgery was G2 NET of ileo-cecal valve. Restaging was carried out by 111 In-Octreotide SPECT/CT and, 1 month later, by 68 Ga-DOTATOC PET/CT. 18 F-FDG PET/C was also carried out. Interventions: 68 Ga-DOTATOC PET/CT showed larger disease that modified disease management from surgery to medical treatment. Outcomes: After an initial improvement in the patient clinical condition, the tumor caused a worsening with the appearance of ascites. Lessons: 68 Ga-DOTA-conjugate PET/CT is appropriate in low and intermediate NET (Ki67 index respectively ≤3% and 3%–20%) characterized by better survival and better response after Peptide Receptor Radionuclide Therapy. 18 F-FDG is mostly useful in high grade (G3) of disease, so that 68 Ga-DOTA-conjugate SUV and 18 F-FDG SUV have an opposite trend in relation to the tumor grade. 68 Ga-DOTATOC PET/CT changes, as in our case, therapeutic management in about 40% of cases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1097/md.0000000000019162 |
| DOI: | 10.1097/MD.0000000000019162 |
| الاتاحة: | http://dx.doi.org/10.1097/md.0000000000019162 https://journals.lww.com/10.1097/MD.0000000000019162 |
| Rights: | http://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.26DE99E3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/md.0000000000019162 |
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