التفاصيل البيبلوغرافية
| العنوان: |
Clinical and cost-effectiveness of contingency management for cannabis use in early psychosis: the CIRCLE randomised clinical trial |
| المؤلفون: |
Rains, LS, Marston, L, Hinton, M, Marwaha, S, Craig, T, Fowler, D, King, M, Omar, RZ, McCrone, P, Spencer, J, Taylor, J, Colman, S, Harder, C, Gilbert, E, Randhawa, A, Labuschagne, K, Jones, C, Stefanidou, T, Christoforou, M, Craig, M, Strang, J, Weaver, T, Johnson, S |
| بيانات النشر: |
BMC |
| سنة النشر: |
2019 |
| المجموعة: |
The University of Melbourne: Digital Repository |
| الوصف: |
BACKGROUND: Cannabis is the most commonly used illicit substance amongst people with psychosis. Continued cannabis use following the onset of psychosis is associated with poorer functional and clinical outcomes. However, finding effective ways of intervening has been very challenging. We examined the clinical and cost-effectiveness of adjunctive contingency management (CM), which involves incentives for abstinence from cannabis use, in people with a recent diagnosis of psychosis. METHODS: CIRCLE was a pragmatic multi-centre randomised controlled trial. Participants were recruited via Early Intervention in Psychosis (EIP) services across the Midlands and South East of England. They had had at least one episode of clinically diagnosed psychosis (affective or non-affective); were aged 18 to 36; reported cannabis use in at least 12 out of the previous 24 weeks; and were not currently receiving treatment for cannabis misuse, or subject to a legal requirement for cannabis testing. Participants were randomised via a secure web-based service 1:1 to either an experimental arm, involving 12 weeks of CM plus a six-session psychoeducation package, or a control arm receiving the psychoeducation package only. The total potential voucher reward in the CM intervention was £240. The primary outcome was time to acute psychiatric care, operationalised as admission to an acute mental health service (including community alternatives to admission). Primary outcome data were collected from patient records at 18 months post-consent by assessors masked to allocation. The trial was registered with the ISRCTN registry, number ISRCTN33576045. RESULTS: Five hundred fifty-one participants were recruited between June 2012 and April 2016. Primary outcome data were obtained for 272 (98%) in the CM (experimental) group and 259 (95%) in the control group. There was no statistically significant difference in time to acute psychiatric care (the primary outcome) (HR 1.03, 95% CI 0.76, 1.40) between groups. By 18 months, 90 (33%) of participants in ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
1741-7015 |
| Relation: |
pii: 10.1186/s12916-019-1395-5; Rains, L. S., Marston, L., Hinton, M., Marwaha, S., Craig, T., Fowler, D., King, M., Omar, R. Z., McCrone, P., Spencer, J., Taylor, J., Colman, S., Harder, C., Gilbert, E., Randhawa, A., Labuschagne, K., Jones, C., Stefanidou, T., Christoforou, M. ,. Johnson, S. (2019). Clinical and cost-effectiveness of contingency management for cannabis use in early psychosis: the CIRCLE randomised clinical trial. BMC MEDICINE, 17 (1), https://doi.org/10.1186/s12916-019-1395-5.; http://hdl.handle.net/11343/227623 |
| الاتاحة: |
http://hdl.handle.net/11343/227623 |
| Rights: |
CC BY ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: |
edsbas.26C5231A |
| قاعدة البيانات: |
BASE |
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