Academic Journal
Understanding the effects of inhaler resistance on particle deposition behaviour – A computational modelling study
| العنوان: | Understanding the effects of inhaler resistance on particle deposition behaviour – A computational modelling study |
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| المؤلفون: | Cai, Xinyu, Dong, Jingliang, Milton-McGurk, Liam, Lee, Ann, Shen, Zhiwei, Chan, Hak-Kim, Kourmatzis, Agisilaos, Cheng, Shaokoon |
| بيانات النشر: | Elsevier BV |
| سنة النشر: | 2023 |
| المجموعة: | Victoria University Melbourne: VU Eprint Repository |
| مصطلحات موضوعية: | 4003 Biomedical engineering, College of Science and Engineering, computational fluid dynamics, dry powder inhaler, inhaler resistance, article deposition |
| الوصف: | Background and objective: Understanding the impact of inhaler resistance on particle transport and deposition in the human upper airway is essential for optimizing inhaler designs, thereby contributing to the enhancement of the therapeutic efficacy of inhaled drug delivery. This study demonstrates the potential effects of inhaler resistance on particle deposition characteristics in an anatomically realistic human oropharynx and the United States Pharmacopeia (USP) throat using computational fluid dynamics (CFD). Method: Magnetic resonance (MR) imaging was performed on a healthy volunteer biting on a small mockup inhaler mouthpiece. Three-dimensional geometry of the oropharynx and mouthpiece were reconstructed from the MR images. CFD simulations coupled with discrete phase modelling were conducted. Inhaled polydisperse particles under two different transient flow profiles with peak inspiratory flow rates (PIFR) of 30 L/min and 60 L/min were investigated. The effect of inhaler mouthpiece resistance was modelled as a porous medium by varying the initial resistance (Ri) and viscous resistance (Rv). Three resistance values, 0.02 kPa0.5minL−1, 0.035 kPa0.5minL−1 and 0.05 kPa0.5 minL−1, were simulated. The inhaler outlet velocity was set to be consistent across all models for both flow rate conditions to enable a meaningful comparison of models with different inhaler resistances. Result: The results from this study demonstrate that investigating the effect of inhaler resistance by solely relying on the USP throat model may yield misleading results. For the geometrically realistic oropharyngeal model, both the pressure and kinetic energy profiles at the mid-sagittal plane of the airway change dramatically when connected to a higher-resistance inhaler. In addition, the geometrically realistic oropharyngeal model appears to have a resistance threshold. When this threshold is surpassed, significant changes in flow dynamics become evident, which is not observed in the USP throat model. Furthermore, this study also reveals ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://vuir.vu.edu.au/48225/; https://doi.org/10.1016/j.compbiomed.2023.107673; https://vuir.vu.edu.au/48225/1/1-s2.0-S0010482523011381-main.pdf; Cai, Xinyu, Dong, Jingliang orcid:0000-0002-2812-6188 , Milton-McGurk, Liam orcid:0000-0002-4294-729X , Lee, Ann orcid:0000-0003-4300-9032 , Shen, Zhiwei orcid:0009-0002-7367-0163 , Chan, Hak-Kim orcid:0000-0002-7054-3137 , Kourmatzis, Agisilaos and Cheng, Shaokoon (2023) Understanding the effects of inhaler resistance on particle deposition behaviour – A computational modelling study. Computers in Biology and Medicine, 167. p. 107673. ISSN 0010-4825 |
| DOI: | 10.1016/j.compbiomed.2023.107673 |
| الاتاحة: | https://vuir.vu.edu.au/48225/ https://doi.org/10.1016/j.compbiomed.2023.107673 http://purl.org/au-research/grants/arc/DE210101549 https://vuir.vu.edu.au/48225/1/1-s2.0-S0010482523011381-main.pdf |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.2690D847 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.compbiomed.2023.107673 |
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