التفاصيل البيبلوغرافية
| العنوان: |
Functional analysis of insecticide resistance mechanisms on medically important and from agriculturally important insects ; Λειτουργική ανάλυση μηχανισμών ανθεκτικότητας σε εντομοκτόνα σε έντομα υγιειονομικής και από έντομα αγροτικής σημασίας |
| المؤلفون: |
Κόκκας, Εμμανουήλ Σ. |
| المساهمون: |
Βόντας, Ιωάννης, Δελιδάκης, Χρήστος, Kiamos, Inga-Siden |
| سنة النشر: |
2022 |
| المجموعة: |
University of Crete: E-Locus / Πανεπιστήμιο Κρήτης |
| مصطلحات موضوعية: |
Κουνούπια, Πυρεθροειδή εντομοκτόνα, Νεονικοτινοειδή εντομοκτόνα, Συνεργισμός, Mosquiotoes, Pyrethroid insecticides, Neonicotinoid insecticides, Synergism |
| الوصف: |
The use of chemical insecticides for the control of destructive insects is one of the most efficient and cost-effective methods employed for their control. However, their constant use in vector control and agriculture over the years has led to the establishment of resistant insect populations, therefore creating an ever growing need to understand the molecular mechanisms that govern insecticide resistance. One of the most widely used insecticide classes in the control of vectors of diseases are pyrethroids, which bind on the voltage gated sodium channel altering its kinetics, whereas neonicotinoids, selective agonists of the acetylcholine receptor, are traditionally used in agriculture, although they have recently started being used in vector control as well. Resistance against pyrethroids is very prevalent in the major malaria vector mosquito Anopheles gambiae. Specific neonicotinoid resistance mechanisms haven’t been identified in mosquitoes yet, although they are common in agricultural pests. In the current bibliography, most studies approach insecticide resistance by examining individual mechanisms whereas here, various resistance mechanisms from medically and agriculturally important insects and their combinations are analyzed. Firstly, pyrethroid insecticide resistance mechanisms utilized by An. gambiae are functionally analyzed using laboratory An. gambiae strains. Specifically, the resistance effect of the L1014F kdr target-site mutation, that is heavily associated with pyrethroid insecticide resistance, in combination with the overexpression of known pyrethroid metabolizing P450 enzyme Cyp6M2 is studied. Mosquitoes harboring the L1014F mutation and overexpressing Cyp6M2 show a synergistic effect between the mechanisms, displaying significantly higher pyrethroid resistance than the sum of the isolated mechanisms. Another object of this study is the determination of the resistance effect conferred by the combination of neonicotinoid resistance mechanisms from the agriculturally important insects Myzus ... |
| نوع الوثيقة: |
text |
| وصف الملف: |
57 σ. : πίν., σχήμ., εικ.; 30 εκ. |
| اللغة: |
English |
| Relation: |
http://elocus.lib.uoc.gr:443/dlib/9/8/5/metadata-dlib-1667384905-795682-27142.tkl; 000451942 |
| الاتاحة: |
http://elocus.lib.uoc.gr:443/dlib/9/8/5/metadata-dlib-1667384905-795682-27142.tkl |
| رقم الانضمام: |
edsbas.262C4748 |
| قاعدة البيانات: |
BASE |