التفاصيل البيبلوغرافية
| العنوان: |
Table_1_Acute Phase Proteins as Early Predictors for Immunotherapy Response in Advanced NSCLC: An Explorative Study.docx |
| المؤلفون: |
Marc A. Schneider (10160787), Adriana Rozy (12021584), Sabine Wrenger (12021587), Petros Christopoulos (10429900), Thomas Muley (87877), Michael Thomas (279566), Michael Meister (120830), Tobias Welte (87188), Joanna Chorostowska-Wynimko (783014), Sabina Janciauskiene (264288) |
| سنة النشر: |
2022 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, NSCLC, checkpoint inhibitors, immunotherapy, acute phase proteins, progression-free survival |
| الوصف: |
In the last decade, targeting the immune system became a promising therapy in advanced lung cancer stages. However, in a clinical follow-up, patient responses to immune checkpoint inhibitors widely differ. Peripheral blood is a minimally invasive source of potential biomarkers to explain these differences. We blindly analyzed serum samples from 139 patients with non-small cell lung cancer prior to anti-PD-1 or anti-PD-L1 therapies to assess whether baseline levels of albumin (ALB), alpha-1 acid glycoprotein (AGP), alpha1-antitrypsin (AAT), alpha2-macroglobulin (A2M), ceruloplasmin (CP), haptoglobin (HP), alpha1-antichymotrypsin (ACT), serum amyloid A (SAA), and high-sensitivity C-reactive protein (hs-CRP), have a predictive value for immunotherapy success. Disease progression-free survival (PFS) was calculated based on RECIST 1.1 criteria. A multivariate Cox regression analysis, including serum levels of acute-phase proteins and clinical parameters, revealed that higher pre-therapeutic levels of HP and CP are independent predictors of a worse PFS. Moreover, a combined panel of HP and CP stratified patients into subgroups. We propose to test this panel as a putative biomarker for assessing the success of immunotherapy in patients with NSCLC. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/Table_1_Acute_Phase_Proteins_as_Early_Predictors_for_Immunotherapy_Response_in_Advanced_NSCLC_An_Explorative_Study_docx/19094207 |
| DOI: |
10.3389/fonc.2022.772076.s004 |
| الاتاحة: |
https://doi.org/10.3389/fonc.2022.772076.s004 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.261A737E |
| قاعدة البيانات: |
BASE |