Academic Journal
Surface Adsorption of the Alpha-Emitter Astatine-211 to Gold Nanoparticles Is Stable In Vivo and Potentially Useful in Radionuclide Therapy
| العنوان: | Surface Adsorption of the Alpha-Emitter Astatine-211 to Gold Nanoparticles Is Stable In Vivo and Potentially Useful in Radionuclide Therapy |
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| المؤلفون: | Sporer, Emanuel, Poulie, Christian B. M., Lindegren, Sture, Aneheim, Emma, Jensen, Holger, Bäck, Tom, Kempen, Paul J., Kjaer, Andreas, Herth, Matthias M., Jensen, Andreas I. |
| المصدر: | Sporer , E , Poulie , C B M , Lindegren , S , Aneheim , E , Jensen , H , Bäck , T , Kempen , P J , Kjaer , A , Herth , M M & Jensen , A I 2021 , ' Surface Adsorption of the Alpha-Emitter Astatine-211 to Gold Nanoparticles Is Stable In Vivo and Potentially Useful in Radionuclide Therapy ' , Journal of Nanotheranostics , vol. 2 , no. 4 , pp. 196-207 . https://doi.org/10.3390/jnt2040012 |
| سنة النشر: | 2021 |
| المجموعة: | Technical University of Denmark: DTU Orbit / Danmarks Tekniske Universitet |
| مصطلحات موضوعية: | Astatine-211, Targeted alpha-therapy, Gold nanoparticles, Radionuclides |
| الوصف: | Targeted α-therapy (TAT) can eradicate tumor metastases while limiting overall toxicity. One of the most promising α-particle emitters is astatine-211 ( 211 At). However, 211 At-carbon bonds are notoriously unstable in vivo and no chelators are available. This hampers its adoption in TAT. In this study, the stability of 211 At on the surface of gold nanoparticles (AuNPs) was investigated. The employed AuNPs had sizes in the 25–50 nm range. Radiolabeling by non-specific surface-adsorption in >99% radiochemical yield was achieved by mixing 211 At and AuNPs both before and after polyethylene glycol (PEG) coating. The resulting 211 At-AuNPs were first challenged by harsh oxidation with sodium hypochlorite, removing roughly 50% of the attached 211 At. Second, incubation in mouse serum followed by a customized stability test, showed a stability of >95% after 4 h in serum. This high stability was further confirmed in an in vivo study, with comparison to a control group of free 211 At. The AuNP-associated 211 At showed low uptake in stomach and thyroid, which are hallmark organs of uptake of free 211 At, combined with long circulation and high liver and spleen uptake, consistent with nanoparticle biodistribution. These results support that gold surface-adsorbed 211 At has high biological stability and is a potentially useful delivery system in TAT. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.3390/jnt2040012 |
| الاتاحة: | https://orbit.dtu.dk/en/publications/7243ea1e-b0cd-4e82-bdba-c27f9b92f06a https://doi.org/10.3390/jnt2040012 https://backend.orbit.dtu.dk/ws/files/265199155/2021_Sporer_Jensen_211At_on_AuNPs.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.26047504 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/jnt2040012 |
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