Academic Journal
New spectrophotometric method for determination of mebendazole by oxidative coupling reaction
| العنوان: | New spectrophotometric method for determination of mebendazole by oxidative coupling reaction |
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| المؤلفون: | Abdulhadi, Rasha Z., Mohammed, Dawood H. |
| المصدر: | International journal of health sciences; Special Issue IV ; 2550-696X ; 2550-6978 ; 10.53730/ijhs.v6nS4.2022 |
| بيانات النشر: | Universidad Tecnica de Manabi |
| سنة النشر: | 2022 |
| المجموعة: | ScienceScholar Publishing (Universidad Tecnica de Manabi) |
| الوصف: | A rapid , simple, accurate and sensitive spectrophotometric method was developed for determination of mebendazole ( MBL ) in pure form and in its pharmaceutical dosages. This method depend on oxidation of MBL with excess amount of N-bromosuccinimide ( NBS ) in acidic medium with standing for complete the reaction , and the oxidized MBL coupled with Rhodamine B to get red product related with MBL amount and measuring the absorbance of surplus dye at 570 nm. A linear calibration curve was obtained over the concentration range 2.5 – 30 μg.ml-1 with correlation coefficient of 0.9992. The molar absorptivity and sandell's sensitivity index values were determined to be 1.476 × 104 L.mol-1.cm-1 and 0.02 μg.cm-2. The limit of detection (LOD) and quantification (LOQ) were calculated to be 0.469 and 1.982 μg.ml-1, respectively . The proposed method has been successfully applied to the determination of MBL in available dosage form, the validity proposed method was confirmed by recovery study via standard addition technique. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://sciencescholar.us/journal/index.php/ijhs/article/view/9337 |
| DOI: | 10.53730/ijhs.v6nS4.9337 |
| الاتاحة: | https://sciencescholar.us/journal/index.php/ijhs/article/view/9337 https://doi.org/10.53730/ijhs.v6nS4.9337 |
| Rights: | Copyright (c) 2022 International journal of health sciences ; http://creativecommons.org/licenses/by-nc-nd/4.0 |
| رقم الانضمام: | edsbas.25F2E41D |
| قاعدة البيانات: | BASE |
| DOI: | 10.53730/ijhs.v6nS4.9337 |
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