Academic Journal
Adherence to a MIND-Like Dietary Pattern, Long-Term Exposure to Fine Particulate Matter Air Pollution, and MRI-Based Measures of Brain Volume: The Women’s Health Initiative Memory Study-MRI
| العنوان: | Adherence to a MIND-Like Dietary Pattern, Long-Term Exposure to Fine Particulate Matter Air Pollution, and MRI-Based Measures of Brain Volume: The Women’s Health Initiative Memory Study-MRI |
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| المؤلفون: | Chen, C, Hayden, K.M, Kaufman, J.D, Espeland, M.A, Whitsel, E.A, Serre, M.L, Vizuete, W, Orchard, T.S, Wang, X, Chui, H.C, DAlton, M.E, Chen, J.-C, Kahe, K |
| المصدر: | Environmental Health Perspectives, 129(12) |
| بيانات النشر: | Public Health Services, US Dept of Health and Human Services |
| سنة النشر: | 2021 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| الوصف: | BACKGROUND: Previous studies suggest that certain dietary patterns and constituents may be beneficial to brain health. Airborne exposures to fine particulate matter [particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5)] are neurotoxic, but the combined effects of dietary patterns and PM2.5 have not been investigated. OBJECTIVES: We examined whether previously reported association between PM2.5 exposure and lower white matter volume (WMV) differed between women whose usual diet during the last 3 months before baseline was more or less consistent with a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND)-like diet, a dietary pattern that may slow neurodegenerative changes. METHODS: This study included 1,302 U.S. women who were 65-79 y old and free of dementia in the period 1996-1998 (baseline). In the period 2005-2006, structural brain magnetic resonance imaging (MRI) scans were performed to estimate normal-appearing brain volumes (excluding areas with evidence of small vessel ischemic disease). Baseline MIND diet scores were derived from a food frequency questionnaire. Three-year average PM2.5 exposure prior to MRI was estimated using geocoded participant addresses and a spatiotemporal model. RESULTS: Average total and temporal lobe WMVs were 0:74 cm3 [95% confidence interval (CI): 0.001, 1.48) and 0:19 cm3 (95% CI: 0.002, 0.37) higher, respectively, with each 0.5-point increase in the MIND score and were 4:16 cm3 (95% CI: -6:99, -1:33) and 1:46 cm3 (95% CI: -2:16, -0:76) lower, respectively, with each interquartile range (IQR) (IQR = 3:22 μg/m3) increase in PM2.5. The inverse association between PM2.5 per IQR and WMV was stronger (p-interaction <0:001) among women with MIND scores below the median (for total WMV, -12:47 cm3; 95% CI: −17:17, −7:78), but absent in women with scores above the median (0:16 cm3; 95% CI: −3:41, 3.72), with similar patterns for WMV in the frontal, parietal, and temporal lobes. For total cerebral and hippocampus brain volumes or WMV in the corpus callosum, the ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://doi.org/10.17615/y3dj-yp11; https://cdr.lib.unc.edu/downloads/g445cq64n?file=thumbnail; https://cdr.lib.unc.edu/downloads/g445cq64n |
| DOI: | 10.17615/y3dj-yp11 |
| الاتاحة: | https://doi.org/10.17615/y3dj-yp11 https://cdr.lib.unc.edu/downloads/g445cq64n?file=thumbnail https://cdr.lib.unc.edu/downloads/g445cq64n |
| رقم الانضمام: | edsbas.25EAC89E |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/y3dj-yp11 |
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