Academic Journal
Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis
| العنوان: | Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis |
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| المؤلفون: | Danielsen, Stine A., Lind, Guro E., Kolberg, Matthias, Holand, Maren, Bjerkehagen, Bodil, Hall, Kirsten Sundby, van den Berg, Eva, Mertens, Fredrik, Smeland, Sigbjorn, Picci, Piero, Lothe, Ragnhild A. |
| المصدر: | Danielsen , S A , Lind , G E , Kolberg , M , Holand , M , Bjerkehagen , B , Hall , K S , van den Berg , E , Mertens , F , Smeland , S , Picci , P & Lothe , R A 2015 , ' Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis ' , Neuro-Oncology , vol. 17 , no. 1 , pp. 63-69 . https://doi.org/10.1093/neuonc/nou140 |
| سنة النشر: | 2015 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | methylation, MPNST, NF1, RASSF1A, survival, SOFT-TISSUE SARCOMAS, PROMOTER METHYLATION, EPIGENETIC INACTIVATION, DNA METHYLATION, SUPPRESSOR GENE, POOR-PROGNOSIS, NF1 PROMOTER, TUMORIGENESIS, HYPERMETHYLATION |
| الوصف: | Background. Malignant peripheral nerve sheath tumor (MPNST) is a rare and highly aggressive disease with no evidence of effect from adjuvant therapy. It is further associated with the hereditary syndrome neurofibromatosis type 1 (NF1). Silencing of the tumor suppressor gene RASSF1A through DNA promoter hypermethylation is known to be involved in cancer development, but its impact in MPNSTs remains unsettled. Methods. The RASSF1A promoter was analyzed by methylation-specific PCR in 113 specimens, including 44 NF1-associated MPNSTs, 47 sporadic MPNSTs, 21 benign neurofibromas, and 1 nonneoplastic nerve sheath control. Results. RASSF1A methylation was found only in the malignant samples (60%) and identified a subgroup among patients with NF1-associated MPNST with a poor prognosis. These patients had a mean 5-year disease-specific survival of 27.3 months (95% CI: 17.2-37.4) versus 47.4 months (95% CI: 37.5-57.2) for NF1 patients with unmethylated promoters, P = 0.014. In multivariate Cox regression analysis, methylated RASSF1A remained an adverse prognostic factor independent of clinical risk factors, P = .013 (hazard ratio: 5.2; 95% CI: 1.4-19.4). Conclusion. A considerable number of MPNST samples display hypermethylation of the RASSF1A gene promoter, and for these tumors, this is the first molecular marker that if validated can characterize a subgroup of patients with inferior prognosis, restricted to individuals with NF1. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://research.rug.nl/en/publications/92e1235e-e4bd-43f0-8b76-9ad2b4c2599c |
| DOI: | 10.1093/neuonc/nou140 |
| الاتاحة: | https://hdl.handle.net/11370/92e1235e-e4bd-43f0-8b76-9ad2b4c2599c https://research.rug.nl/en/publications/92e1235e-e4bd-43f0-8b76-9ad2b4c2599c https://doi.org/10.1093/neuonc/nou140 https://pure.rug.nl/ws/files/46054955/Methylated_RASSF1A_in_malignant_peripheral_nerve_sheath_tumors_identifies_neurofibromatosis_type.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.25E9D75 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/neuonc/nou140 |
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