Book
Vitamin B12 photoreceptors
| العنوان: | Vitamin B12 photoreceptors |
|---|---|
| المؤلفون: | Padmanabhan, Subramanian, Pérez-Castaño, Ricardo, Osete-Alcaraz, Lucía, Polanco, María Carmen, Elías-Arnanz, Montserrat |
| المساهمون: | Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Fundación Séneca |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2022 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | CarH, Carotenogenesis, Cobalamin, Gene regulation, Optogenetics, Photoreceptors, Photoregulation, Vitamin B(12) |
| الوصف: | 36 pags., 1 figs., 1 tab. -- Chapter Six ; Photoreceptor proteins enable living organisms to sense light and transduce this signal into biochemical outputs to elicit appropriate cellular responses. Their light sensing is typically mediated by covalently or noncovalently bound molecules called chromophores, which absorb light of specific wavelengths and modulate protein structure and biological activity. Known photoreceptors have been classified into about ten families based on the chromophore and its associated photosensory domain in the protein. One widespread photoreceptor family uses coenzyme B12 or 5'-deoxyadenosylcobalamin, a biological form of vitamin B12, to sense ultraviolet, blue, or green light, and its discovery revealed both a new type of photoreceptor and a novel functional facet of this vitamin, best known as an enzyme cofactor. Large strides have been made in our understanding of how these B12-based photoreceptors function, high-resolution structural descriptions of their functional states are available, as are details of their unusual photochemistry. Additionally, they have inspired notable applications in optogenetics/optobiochemistry and synthetic biology. Here, we provide an overview of what is currently known about these B12-based photoreceptors, their discovery, distribution, molecular mechanism of action, and the structural and photochemical basis of how they orchestrate signal transduction and gene regulation, and how they have been used to engineer optogenetic control of protein activities in living cells. ; We thank our group and research collaborators who contributed to the work on B12 photoreceptors, currently supported by the Ministerio de Ciencia, Innovacion y Universidades (MCIU)/Agencia Estatal de Investigacion (AEI)-Spain/European Regional Development Fund (ERDF) grants PGC2018-094635-B-C21 to M.E.-A. and PGC2018- 094635-B-C22 to S.P., both funded by MCIU/AEI 10.13039/501100011033 and by ‘ERDF A way of making Europe’; Ph.D. contract to R. P.-C (BES-2016-076883, MINECO/AEI) and ... |
| نوع الوثيقة: | book part |
| اللغة: | English |
| ردمك: | 978-0-323-99223-7 0-323-99223-4 |
| تدمد: | 0083-6729 |
| Relation: | #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-094635-B-C21/ES/SEÑALIZACION DE ESTRESES EN LA ENVOLTURA CELULAR Y LOS MECANISMOS ASOCIADOS DE REGULACION GENICA EN MYXOCOCCUS XANTHUS: ASPECTOS FUNCIONALES Y EVOLUTIVOS/; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-094635-B-C22/ES/SEÑALIZACION DE ESTRESES EN LA ENVOLTURA CELULAR Y LOS MECANISMOS ASOCIADOS DE REGULACION GENICA EN MYXOCOCCUS XANTHUS: ESTUDIOS ESTRUCTURALES/; Vitamins and hormones; Postprint; https://doi.org/10.1016/bs.vh.2022.01.007; Sí; Vitamin B12 (2022); http://hdl.handle.net/10261/288729; 2-s2.0-85126119742; https://api.elsevier.com/content/abstract/scopus_id/85126119742 |
| DOI: | 10.1016/bs.vh.2022.01.007 |
| الاتاحة: | http://hdl.handle.net/10261/288729 https://doi.org/10.1016/bs.vh.2022.01.007 https://api.elsevier.com/content/abstract/scopus_id/85126119742 |
| Rights: | none |
| رقم الانضمام: | edsbas.25D1B258 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780323992237 0323992234 |
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| تدمد: | 00836729 |
| DOI: | 10.1016/bs.vh.2022.01.007 |